Abstract
(Chemical Equation Presented) Control of the migration tendency: The regiodivergent 1,2-rearrangement of asiloxy aldehydes bearing α-aryl and α-alkyl substituents into α-siloxy ketones has been realized by using different aluminum Lewis acid catalyst/solvent systems (see scheme). The scope of this unprecedented protocol has been investigated with various substrates and clearly demonstrates its utility for the selective synthesis of two structural isomers from one substrate.
| Original language | English |
|---|---|
| Pages (from-to) | 5203-5206 |
| Number of pages | 4 |
| Journal | Angewandte Chemie - International Edition |
| Volume | 47 |
| Issue number | 28 |
| DOIs | |
| Publication status | Published - 2008 Jun 27 |
| Externally published | Yes |
Keywords
- Aluminum
- Lewis acids
- Rearrangement
- Regioselectivity
- Synthetic methods
ASJC Scopus subject areas
- Catalysis
- General Chemistry
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