Complex-type chromosomal exchanges in blood lymphocytes during radiation therapy correlate with acute toxicity

Shigeru Yamada; Marco Durante; Koichi Ando; Yoshiya Furusawa; Tetsuya Kawata; Hideyuki Majima; Hirohiko Tsujii

doi:10.1016/S0304-3835(99)00405-X

Complex-type chromosomal exchanges in blood lymphocytes during radiation therapy correlate with acute toxicity

Shigeru Yamada, Marco Durante, Koichi Ando, Yoshiya Furusawa, Tetsuya Kawata, Hideyuki Majima, Hirohiko Tsujii

Department of Radiology

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Abstract

The new method of chemical-induced premature chromosome condensation combined with fluorescence in situ hybridization was used to analyze chromosomal damage in peripheral blood mononuclear lymphocytes of patients undergoing radiation treatment for esophageal cancer with high-energy X-rays or accelerated carbon ions at the National Institute of Radiological Sciences (Chiba, Japan). Total number of aberrant cells correlated with radiation field size, but no correlation was found with acute toxicity. A high frequency of complex-type exchanges were also recorded. This aberration type presented a high individual variability, and correlated well with the acute morbidity. Cytogenetic analysis by interphase chromosome painting is proposed as a useful tool for monitoring normal tissue effects during radiotherapy. (C) 2000 Elsevier Science Ireland Ltd.

Original language	English
Pages (from-to)	215-221
Number of pages	7
Journal	Cancer Letters
Volume	150
Issue number	2
DOIs	https://doi.org/10.1016/S0304-3835(99)00405-X
Publication status	Published - 2000 Mar 31

Keywords

Chromosomal aberrations
Complex exchanges
Morbidity
Oesophageal cancer
Predictive assay
Radiotherapy

ASJC Scopus subject areas

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/S0304-3835(99)00405-X

Cite this

@article{6e1fcc014aff4921a1e97814881add1b,

title = "Complex-type chromosomal exchanges in blood lymphocytes during radiation therapy correlate with acute toxicity",

abstract = "The new method of chemical-induced premature chromosome condensation combined with fluorescence in situ hybridization was used to analyze chromosomal damage in peripheral blood mononuclear lymphocytes of patients undergoing radiation treatment for esophageal cancer with high-energy X-rays or accelerated carbon ions at the National Institute of Radiological Sciences (Chiba, Japan). Total number of aberrant cells correlated with radiation field size, but no correlation was found with acute toxicity. A high frequency of complex-type exchanges were also recorded. This aberration type presented a high individual variability, and correlated well with the acute morbidity. Cytogenetic analysis by interphase chromosome painting is proposed as a useful tool for monitoring normal tissue effects during radiotherapy. (C) 2000 Elsevier Science Ireland Ltd.",

keywords = "Chromosomal aberrations, Complex exchanges, Morbidity, Oesophageal cancer, Predictive assay, Radiotherapy",

author = "Shigeru Yamada and Marco Durante and Koichi Ando and Yoshiya Furusawa and Tetsuya Kawata and Hideyuki Majima and Hirohiko Tsujii",

note = "Funding Information: Work supported by NIRS Grant on Heavy-ion Medical Research. During this research activity, M.D. was on leave of absence from the University of Naples {\textquoteleft}Federico II{\textquoteright} (Italy), supported by Science and Technology Agency (Japan) fellowship n. 196121.",

year = "2000",

month = mar,

day = "31",

doi = "10.1016/S0304-3835(99)00405-X",

language = "English",

volume = "150",

pages = "215--221",

journal = "Cancer Letters",

issn = "0304-3835",

publisher = "Elsevier Ireland Ltd",

number = "2",

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TY - JOUR

T1 - Complex-type chromosomal exchanges in blood lymphocytes during radiation therapy correlate with acute toxicity

AU - Yamada, Shigeru

AU - Durante, Marco

AU - Ando, Koichi

AU - Furusawa, Yoshiya

AU - Kawata, Tetsuya

AU - Majima, Hideyuki

AU - Tsujii, Hirohiko

N1 - Funding Information: Work supported by NIRS Grant on Heavy-ion Medical Research. During this research activity, M.D. was on leave of absence from the University of Naples ‘Federico II’ (Italy), supported by Science and Technology Agency (Japan) fellowship n. 196121.

PY - 2000/3/31

Y1 - 2000/3/31

N2 - The new method of chemical-induced premature chromosome condensation combined with fluorescence in situ hybridization was used to analyze chromosomal damage in peripheral blood mononuclear lymphocytes of patients undergoing radiation treatment for esophageal cancer with high-energy X-rays or accelerated carbon ions at the National Institute of Radiological Sciences (Chiba, Japan). Total number of aberrant cells correlated with radiation field size, but no correlation was found with acute toxicity. A high frequency of complex-type exchanges were also recorded. This aberration type presented a high individual variability, and correlated well with the acute morbidity. Cytogenetic analysis by interphase chromosome painting is proposed as a useful tool for monitoring normal tissue effects during radiotherapy. (C) 2000 Elsevier Science Ireland Ltd.

AB - The new method of chemical-induced premature chromosome condensation combined with fluorescence in situ hybridization was used to analyze chromosomal damage in peripheral blood mononuclear lymphocytes of patients undergoing radiation treatment for esophageal cancer with high-energy X-rays or accelerated carbon ions at the National Institute of Radiological Sciences (Chiba, Japan). Total number of aberrant cells correlated with radiation field size, but no correlation was found with acute toxicity. A high frequency of complex-type exchanges were also recorded. This aberration type presented a high individual variability, and correlated well with the acute morbidity. Cytogenetic analysis by interphase chromosome painting is proposed as a useful tool for monitoring normal tissue effects during radiotherapy. (C) 2000 Elsevier Science Ireland Ltd.

KW - Chromosomal aberrations

KW - Complex exchanges

KW - Morbidity

KW - Oesophageal cancer

KW - Predictive assay

KW - Radiotherapy

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U2 - 10.1016/S0304-3835(99)00405-X

DO - 10.1016/S0304-3835(99)00405-X

M3 - Article

C2 - 10704745

AN - SCOPUS:0033997938

SN - 0304-3835

VL - 150

SP - 215

EP - 221

JO - Cancer Letters

JF - Cancer Letters

IS - 2

ER -

Complex-type chromosomal exchanges in blood lymphocytes during radiation therapy correlate with acute toxicity

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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