Components of the SWI/SNF complex are required for asymmetric cell division in C. elegans

Hitoshi Sawa, Hiroko Kouike, Hideyuki Okano

Research output: Contribution to journalArticlepeer-review

80 Citations (Scopus)


Asymmetric cell division is a fundamental process that produces cellular diversity during development. We have identified two mutants in C. elegans (psa-1 and psa-4) in which the asymmetry of T cell division is disrupted. psa-1 and psa-4 encode homologs of yeast SW13 and SW12/SNF2, respectively, which are components of the SWI/SNF complex. We show by RNA interference assay that homologs of other components of SWI/SNF are also involved in T cell division. psa-1 and psa-4 are likely to be required in the T cell during mitosis to cause asymmetric cell division. Because the SWI/SNF complex is required for asymmetric division in S. cerevisiae, these results demonstrate that at least some aspects of the mechanism of asymmetric cell division are conserved between yeast and a multicellular organism.

Original languageEnglish
Pages (from-to)617-624
Number of pages8
JournalMolecular Cell
Issue number3
Publication statusPublished - 2000
Externally publishedYes

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology


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