Concentration and distribution of dioxins and related compounds in human tissues

Takao Iida, Takashi Todaka, Hironori Hirakawa, Tsuguhide Hori, Kazuhiro Tobiishi, Takahiko Matsueda, Shaw Watanabe, Taketo Yamada

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)


Polychlorinated dibenzo-p-dioxin, polychlorinated dibenzofuran and dioxin-like polychlorinated biphenyl concentrations in human blood, lung, liver, bile, pancreas, spleen, kidney and mesentery fat were determined to assess the concentrations and distribution of these chemicals in human tissues from 20 donors. The mean TEQ concentrations in blood, lung, liver, bile, spleen, pancreas, kidney and mesentery fat were 119, 178, 228, 50, 113, 163, 138 and 139 pg TEQ/g lipid, respectively. Parallel levels were seen in the blood, spleen, kidney and mesentery fat; in the lungs and pancreas, the levels were somewhat higher. Among the organ tissues samples, the highest concentration was observed in the liver and the lowest in the bile. Mean total-TEQ concentration of the liver was about 4.5 times higher than that of bile. Positive correlations were observed among the concentrations of dioxins in various tissues. However, the concentrations in bile were not correlated with any tissues. It is suggested that the distribution behavior of dioxin-like congeners in human tissues varies among tissues and the kinds of congeners ingested. To evaluate the relationship between the accumulation levels of dioxins and their pathophysiological significance or risk, data must be accumulated from a more extensive group of human samples.

Original languageEnglish
Pages (from-to)S263-S271
Issue number9
Publication statusPublished - 2007 Apr
Externally publishedYes


  • Coplanar polychlorinated biphenyls
  • Distribution
  • Human tissues
  • Polychlorinated dibenzo-p-dioxins
  • Polychlorinated dibenzofurans
  • Tissue concentration

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Pollution
  • Chemistry(all)
  • Health, Toxicology and Mutagenesis
  • Environmental Engineering
  • Environmental Chemistry


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