Concurrent de novo Thymoma-associated Paraneoplastic Type 1 Autoimmune Hepatitis and Pure Red Cell Aplasia after Thymectomy: A Case Report and Literature Review

Rie Sakata; Po Sung Chu; Miho Kawaida; Katsura Emoto; Masatoshi Sakurai; Risa Nishida; Keisuke Asakura; Rei Morikawa; Nobuhito Taniki; Keisuke Kataoka; Takanori Kanai; Nobuhiro Nakamoto

doi:10.2169/internalmedicine.9743-22

Concurrent de novo Thymoma-associated Paraneoplastic Type 1 Autoimmune Hepatitis and Pure Red Cell Aplasia after Thymectomy: A Case Report and Literature Review

Rie Sakata, Po Sung Chu, Miho Kawaida, Katsura Emoto, Masatoshi Sakurai, Risa Nishida, Keisuke Asakura, Rei Morikawa, Nobuhito Taniki, Keisuke Kataoka, Takanori Kanai, Nobuhiro Nakamoto

Research output: Contribution to journal › Article › peer-review

Abstract

The precise manipulation of immune tolerance is the holy grail of immunotherapies for both autoimmunity and cancer immunity. Thymomas are well known to be associated with autoimmune diseases. The exact mechanism by which autoreactivity is induced after thymectomy remains to be elucidated. We herein present the case of a 50-year-old lady with concurrent de novo type 1 autoimmune hepatitis (AIH) and pure red cell aplasia (PRCA), 1 month after undergoing a successful total thymectomy for combined squamous cell carcinoma and thymoma (Masaoka stage II). Corticosteroids yielded short-term effects for both AIH and PRCA. Literature on thymoma-associated AIH, an extremely rare immune-related comorbidity, was also reviewed.

Original language	English
Pages (from-to)	243-249
Number of pages	7
Journal	Internal Medicine
Volume	62
Issue number	2
DOIs	https://doi.org/10.2169/internalmedicine.9743-22
Publication status	Published - 2023

Keywords

autoimmunity
immune tolerance
immunosuppression
thymic epithelial tumors

ASJC Scopus subject areas

Internal Medicine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.2169/internalmedicine.9743-22

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Sakata, R., Chu, P. S., Kawaida, M., Emoto, K., Sakurai, M., Nishida, R., Asakura, K., Morikawa, R., Taniki, N., Kataoka, K., Kanai, T., & Nakamoto, N. (2023). Concurrent de novo Thymoma-associated Paraneoplastic Type 1 Autoimmune Hepatitis and Pure Red Cell Aplasia after Thymectomy: A Case Report and Literature Review. Internal Medicine, 62(2), 243-249. https://doi.org/10.2169/internalmedicine.9743-22

Sakata, R, Chu, PS , Kawaida, M, Emoto, K, Sakurai, M, Nishida, R, Asakura, K, Morikawa, R, Taniki, N , Kataoka, K , Kanai, T & Nakamoto, N 2023, 'Concurrent de novo Thymoma-associated Paraneoplastic Type 1 Autoimmune Hepatitis and Pure Red Cell Aplasia after Thymectomy: A Case Report and Literature Review', Internal Medicine, vol. 62, no. 2, pp. 243-249. https://doi.org/10.2169/internalmedicine.9743-22

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abstract = "The precise manipulation of immune tolerance is the holy grail of immunotherapies for both autoimmunity and cancer immunity. Thymomas are well known to be associated with autoimmune diseases. The exact mechanism by which autoreactivity is induced after thymectomy remains to be elucidated. We herein present the case of a 50-year-old lady with concurrent de novo type 1 autoimmune hepatitis (AIH) and pure red cell aplasia (PRCA), 1 month after undergoing a successful total thymectomy for combined squamous cell carcinoma and thymoma (Masaoka stage II). Corticosteroids yielded short-term effects for both AIH and PRCA. Literature on thymoma-associated AIH, an extremely rare immune-related comorbidity, was also reviewed.",

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AU - Sakurai, Masatoshi

AU - Nishida, Risa

AU - Asakura, Keisuke

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AB - The precise manipulation of immune tolerance is the holy grail of immunotherapies for both autoimmunity and cancer immunity. Thymomas are well known to be associated with autoimmune diseases. The exact mechanism by which autoreactivity is induced after thymectomy remains to be elucidated. We herein present the case of a 50-year-old lady with concurrent de novo type 1 autoimmune hepatitis (AIH) and pure red cell aplasia (PRCA), 1 month after undergoing a successful total thymectomy for combined squamous cell carcinoma and thymoma (Masaoka stage II). Corticosteroids yielded short-term effects for both AIH and PRCA. Literature on thymoma-associated AIH, an extremely rare immune-related comorbidity, was also reviewed.

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Concurrent de novo Thymoma-associated Paraneoplastic Type 1 Autoimmune Hepatitis and Pure Red Cell Aplasia after Thymectomy: A Case Report and Literature Review

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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