Conjunctival Epithelial Ingrowth after Penetrating Keratoplasty

Miki Hata-Mizuno, Emi Ingaki, Hiroto Mitamura, Yuichi Uchino, Kazuo Tsubota, Shigeto Shimmura

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


Purpose:To report a case of conjunctival epithelial ingrowth after penetrating keratoplasty.Methods:A 57-year-old woman with herpetic corneal keratitis, endotheliitis, and bullous keratopathy underwent penetrating keratoplasty (PKP) and secondary cataract surgery. One month after cataract surgery, an epithelial ingrowth was observed at the 5 o'clock donor host junction. Ingrowth extended into the anterior chamber and along the iris surface by 9 months. Another PKP was performed, and the excised graft was submitted for histopathology.Results:The graft showed CK13-positive and CK3-negative cells lining the endothelial surface, indicating the conjunctival origin of ingrown epithelium. Ten months postoperatively, no recurrence of ingrowth was observed.Conclusions:We experienced a rare case of conjunctival epithelial ingrowth after penetrating keratoplasty. There was no recurrence of the ingrowth after surgical removal, and the conjunctival origin may explain the relatively benign course of the complication.

Original languageEnglish
Pages (from-to)1181-1183
Number of pages3
Issue number9
Publication statusPublished - 2020 Sept 1


  • cytokeratin 13
  • cytokeratin 3
  • epithelial ingrowth

ASJC Scopus subject areas

  • Ophthalmology


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