Conjunctival epithelium expression of HLA-DR in dry eye patients

Kazuo Tsubota, Tsutomu Fujihara, Keiko Saito, Tsutomu Takeuchi

Research output: Contribution to journalArticlepeer-review

97 Citations (Scopus)


Purpose: To compare conjunctival epithelium expression of HLA-DR and ICAM-1 with tear dynamics and ocular surface parameters. Methods: Brush cytology and flow cytometry were used to quantitatively analyze HLA-DR and ICAM-1 expression in 28 dry eye patients. Results: HLA-DR was expressed in 66% of the conjunctival cells of dry eye patients. This expression correlates with that of ICAM-1, as well as with the Schirmer test results (p<0.05). Conclusion: This study confirmed that dry eye consists not only of ocular surface desiccation, but also of upregulation of the HLA-DR and ICAM-1 molecule in the conjunctival epithelium, possibly resulting in increased inflammation.

Original languageEnglish
Pages (from-to)16-19
Number of pages4
Issue number1
Publication statusPublished - 1999


  • Conjunctival epithelium
  • Dry eye
  • Flow cytometry
  • Fluorescein staining
  • HLA-DR
  • Rose bengal staining
  • Sjogren's syndrome

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems


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