Constituents of the Seed of Malva verticillata: VI: 1) Characterization and Immunological Activities of a Novel Acidic Polysaccharide

Haruki Yamada; Ryoko Gonda; Masashi Tomoda; Mieko Kanari; Noriko Shimizu

doi:10.1248/cpb.38.2771

Constituents of the Seed of Malva verticillata: VI: ¹⁾ Characterization and Immunological Activities of a Novel Acidic Polysaccharide

Haruki Yamada, Ryoko Gonda, Masashi Tomoda, Mieko Kanari, Noriko Shimizu

School of Pharmacy

Research output: Contribution to journal › Article › peer-review

31 Citations (Scopus)

Abstract

A novel acidic polysaccharide, designated as MVS-VI, was isolated from the seeds of Malva verticillata L. It was homogeneous on electrophoresis and gel chromatography, and its molecular mass was estimated to be 26000. It is composed of L-arabinose: D-xylose: D-galactose: D-glucose: L-rhamnose: D-galacturonic acid in the molar ratio of 30:15:20:3:2:10, in addition to small amounts of peptide moiety. Methylation analysis, carbon-13 nuclear magnetic resonance and periodate oxidation studies indicated its structural features to have mainly acidic α-arabino-3,6-β-galactan type structural units. MVS-VI showed significant reticuloendothelial system-potentiating activity in a carbon clearance test, and it possesses remarkable anti-complementary activity.

Original language	English
Pages (from-to)	2771-2774
Number of pages	4
Journal	Chemical and Pharmaceutical Bulletin
Volume	38
Issue number	10
DOIs	https://doi.org/10.1248/cpb.38.2771
Publication status	Published - 1990

Keywords

MVS-VI
Malva verticillata
acidic arabinogalactan
anti-complementary activity
immunological activity
polysaccharide structure
reticuloendothelial system
seed

ASJC Scopus subject areas

General Chemistry
Drug Discovery

Access to Document

10.1248/cpb.38.2771

Cite this

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title = "Constituents of the Seed of Malva verticillata: VI: 1) Characterization and Immunological Activities of a Novel Acidic Polysaccharide",

abstract = "A novel acidic polysaccharide, designated as MVS-VI, was isolated from the seeds of Malva verticillata L. It was homogeneous on electrophoresis and gel chromatography, and its molecular mass was estimated to be 26000. It is composed of L-arabinose: D-xylose: D-galactose: D-glucose: L-rhamnose: D-galacturonic acid in the molar ratio of 30:15:20:3:2:10, in addition to small amounts of peptide moiety. Methylation analysis, carbon-13 nuclear magnetic resonance and periodate oxidation studies indicated its structural features to have mainly acidic α-arabino-3,6-β-galactan type structural units. MVS-VI showed significant reticuloendothelial system-potentiating activity in a carbon clearance test, and it possesses remarkable anti-complementary activity.",

keywords = "MVS-VI, Malva verticillata, acidic arabinogalactan, anti-complementary activity, immunological activity, polysaccharide structure, reticuloendothelial system, seed",

author = "Haruki Yamada and Ryoko Gonda and Masashi Tomoda and Mieko Kanari and Noriko Shimizu",

year = "1990",

doi = "10.1248/cpb.38.2771",

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T2 - VI: 1) Characterization and Immunological Activities of a Novel Acidic Polysaccharide

AU - Yamada, Haruki

AU - Gonda, Ryoko

AU - Tomoda, Masashi

AU - Kanari, Mieko

AU - Shimizu, Noriko

PY - 1990

Y1 - 1990

N2 - A novel acidic polysaccharide, designated as MVS-VI, was isolated from the seeds of Malva verticillata L. It was homogeneous on electrophoresis and gel chromatography, and its molecular mass was estimated to be 26000. It is composed of L-arabinose: D-xylose: D-galactose: D-glucose: L-rhamnose: D-galacturonic acid in the molar ratio of 30:15:20:3:2:10, in addition to small amounts of peptide moiety. Methylation analysis, carbon-13 nuclear magnetic resonance and periodate oxidation studies indicated its structural features to have mainly acidic α-arabino-3,6-β-galactan type structural units. MVS-VI showed significant reticuloendothelial system-potentiating activity in a carbon clearance test, and it possesses remarkable anti-complementary activity.

AB - A novel acidic polysaccharide, designated as MVS-VI, was isolated from the seeds of Malva verticillata L. It was homogeneous on electrophoresis and gel chromatography, and its molecular mass was estimated to be 26000. It is composed of L-arabinose: D-xylose: D-galactose: D-glucose: L-rhamnose: D-galacturonic acid in the molar ratio of 30:15:20:3:2:10, in addition to small amounts of peptide moiety. Methylation analysis, carbon-13 nuclear magnetic resonance and periodate oxidation studies indicated its structural features to have mainly acidic α-arabino-3,6-β-galactan type structural units. MVS-VI showed significant reticuloendothelial system-potentiating activity in a carbon clearance test, and it possesses remarkable anti-complementary activity.

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KW - Malva verticillata

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KW - immunological activity

KW - polysaccharide structure

KW - reticuloendothelial system

KW - seed

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