Construction of stable capillary networks is required to provide sufficient oxygen and nutrients to the deep region of thick tissues, which is important in the context of 3D tissue engineering. Although conventional in vitro culture models have been used to investigate the mechanism of capillary formation, recent advances in microfluidics technologies allowed us to control biophysical and biochemical culture environments more precisely, which led to the construction of functional and stable capillary networks. In this study, endothelial cells and mesenchymal stem cells were co-cultured in microfluidic devices to construct stable capillary networks, which resulted in the construction of luminal structures covered by pericytes. Interactions between endothelial cells and mesenchymal stem cells are also discussed in the context of capillary formation.
|Title of host publication
|Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
|Institute of Electrical and Electronics Engineers Inc.
|Number of pages
|Published - 2015 Nov 4
|37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2015 - Milan, Italy
Duration: 2015 Aug 25 → 2015 Aug 29
|37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2015
|15/8/25 → 15/8/29
ASJC Scopus subject areas
- Computer Vision and Pattern Recognition
- Signal Processing
- Biomedical Engineering
- Health Informatics