Controlled synthesis of 3D multi-compartmental particles with centrifuge-based microdroplet formation from a multi-barrelled capillary

Kazuki Maeda; Hiroaki Onoe; Masahiro Takinoue; Shoji Takeuchi

doi:10.1002/adma.201102560

Controlled synthesis of 3D multi-compartmental particles with centrifuge-based microdroplet formation from a multi-barrelled capillary

Kazuki Maeda, Hiroaki Onoe, Masahiro Takinoue, Shoji Takeuchi

Research output: Contribution to journal › Article › peer-review

201 Citations (Scopus)

Abstract

Controlled synthesis of micro multi-compartmental particles using a centrifuge droplet shooting device (CDSD) is reported. Sodium alginate solutions introduced in a multi-barreled capillary form droplets at the capillary orifice under ultrahigh gravity and gelify in a CaCl ₂ solution. The size, shape, and compartmentalization of the particles are controlled. Co-encapsulation of Jurkat cells and magnetic colloids into Janus particles is demonstrated. The Janus particles present sensitive reaction toward magnetic fields, while the viability of the encapsulated cells is 91%.

Original language	English
Pages (from-to)	1340-1346
Number of pages	7
Journal	Advanced Materials
Volume	24
Issue number	10
DOIs	https://doi.org/10.1002/adma.201102560
Publication status	Published - 2012 Mar 8
Externally published	Yes

Keywords

anisotropic particles
cell-encapsulation
hydrogels
microfabrication
microfluidics

ASJC Scopus subject areas

Materials Science(all)
Mechanics of Materials
Mechanical Engineering

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abstract = "Controlled synthesis of micro multi-compartmental particles using a centrifuge droplet shooting device (CDSD) is reported. Sodium alginate solutions introduced in a multi-barreled capillary form droplets at the capillary orifice under ultrahigh gravity and gelify in a CaCl 2 solution. The size, shape, and compartmentalization of the particles are controlled. Co-encapsulation of Jurkat cells and magnetic colloids into Janus particles is demonstrated. The Janus particles present sensitive reaction toward magnetic fields, while the viability of the encapsulated cells is 91%.",

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AU - Maeda, Kazuki

AU - Onoe, Hiroaki

AU - Takinoue, Masahiro

AU - Takeuchi, Shoji

PY - 2012/3/8

Y1 - 2012/3/8

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AB - Controlled synthesis of micro multi-compartmental particles using a centrifuge droplet shooting device (CDSD) is reported. Sodium alginate solutions introduced in a multi-barreled capillary form droplets at the capillary orifice under ultrahigh gravity and gelify in a CaCl 2 solution. The size, shape, and compartmentalization of the particles are controlled. Co-encapsulation of Jurkat cells and magnetic colloids into Janus particles is demonstrated. The Janus particles present sensitive reaction toward magnetic fields, while the viability of the encapsulated cells is 91%.

KW - anisotropic particles

KW - cell-encapsulation

KW - hydrogels

KW - microfabrication

KW - microfluidics

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Controlled synthesis of 3D multi-compartmental particles with centrifuge-based microdroplet formation from a multi-barrelled capillary

Abstract

Keywords

ASJC Scopus subject areas

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