Corneal higher-order aberrations in eyes with chronic ocular graft-versus-host disease

Eisuke Shimizu, Naohiko Aketa, Hiroyuki Yazu, Miki Uchino, Mizuka Kamoi, Yasunori Sato, Kazuo Tsubota, Yoko Ogawa

Research output: Contribution to journalArticlepeer-review

17 Citations (Scopus)


Purpose: Chronic ocular graft-versus-host disease (GVHD) is a long-term complication after hematopoietic stem cell transplantation (HSCT) and leads to irreversible visual morbidity due to severe ocular surface impairments including visual disfunction. However, knowledge about the optical function in chronic ocular GVHD is limited because it is difficult to assess quantitative optical function objectively. The development of anterior segment optical coherence tomography has allowed objective quantification of optical function by evaluating corneal higher-order aberrations (HOAs). Therefore, we applied this quantification in chronic ocular GVHD patients and verified the correlation between corneal HOAs and visual acuity. Methods: We retrospectively reviewed chronic ocular GVHD patients and the recipients after HSCT. Then, analyzed the relationship between visual function and the severity of chronic ocular GVHD. Results: The eyes of patients with chronic ocular GVHD had higher corneal HOAs than those of non-GVHD patients (HOAs; 0.481 ± 0.306 vs 0.254 ± 0.084, and 0.917 ± 0.609 vs 0.529 ± 0.130. P < 0.001, and 0.002. 4-mm and 6-mm diameters respectively. Corneal HOAs were correlated with the severity of chronic ocular GVHD (r = 0.436. P < 0.001). Moreover, corneal HOAs were correlated with visual acuity, especially in eyes with severe chronic ocular GVHD cases (HOAs; 4-mm r = 0.636. P = 0.036. Total 6-mm r = 0.871. P =<0.001). Conclusions: We succeed to assess the objective value in the optical function of the chronic ocular GVHD. Quantification of corneal HOAs could be an objective evaluation to assess optical function in eyes with chronic ocular GVHD.

Original languageEnglish
Pages (from-to)98-107
Number of pages10
JournalOcular Surface
Issue number1
Publication statusPublished - 2020 Jan


  • Dry eye disease
  • Graft-versus-host disease
  • Higher-order aberration
  • Irregular astigmatism
  • Visual acuity

ASJC Scopus subject areas

  • Ophthalmology


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