TY - JOUR
T1 - Corneal Sensory Experience via Transient Receptor Potential Vanilloid 1 Accelerates the Maturation of Neonatal Tearing
AU - Jin, Kai
AU - Imada, Toshihiro
AU - Nakamura, Shigeru
AU - Izuta, Yusuke
AU - Oonishi, Erina
AU - Shibuya, Michiko
AU - Sakaguchi, Hisayo
AU - Tanabe, Hirotaka
AU - Ito, Masataka
AU - Katanosaka, Kimiaki
AU - Tsubota, Kazuo
N1 - Funding Information:
Supported by Grants-in-Aid for Scientific Research (KAKENHI) grant 17K16983 (T.I.). We thank Dr. Mamoru Shibata (Keio University School of Medicine, Tokyo, Japan) for providing TRPM8 knockout mice and the Collaborative Research Resources (Keio University School of Medicine) for technical assistance. K.J. T.I. and S.N. conceived and designed the study; K.J. T.I. Y.I. E.O. M.S. and H.S. performed the experiments and analyzed the data; M.I. performed the transmission electron microscopy analysis; K.K. M.I. H.T. and K.T. critically interpreted the results; K.J. T.I. S.N. and K.T. wrote the article; all authors participated in this study.
Publisher Copyright:
© 2019 American Society for Investigative Pathology
PY - 2019/9
Y1 - 2019/9
N2 - Tearing maturates rapidly after birth, and external environmental challenges play a key role in promoting lacrimal functional maturation. However, little is known about the facilitative factors underlying this developmental process or the potential of application of these factors to treat hypofunction of the lacrimal gland. In this study, eye opening and the subsequent ocular surface sensory experience, which is thought to be involved in postnatal maturation of lacrimal function, were investigated. Our results demonstrated that eye opening after birth is essential for the maturation of neonatal tearing. The maturation process of lacrimal function is dependent on the ocular surface sensory experience via transient receptor potential cation channel subfamily member 1 after birth. This study provides, for the first time, important evidence of the sensory experience of the ocular surface in relation to the maturation of functional tear secretion during the postnatal period.
AB - Tearing maturates rapidly after birth, and external environmental challenges play a key role in promoting lacrimal functional maturation. However, little is known about the facilitative factors underlying this developmental process or the potential of application of these factors to treat hypofunction of the lacrimal gland. In this study, eye opening and the subsequent ocular surface sensory experience, which is thought to be involved in postnatal maturation of lacrimal function, were investigated. Our results demonstrated that eye opening after birth is essential for the maturation of neonatal tearing. The maturation process of lacrimal function is dependent on the ocular surface sensory experience via transient receptor potential cation channel subfamily member 1 after birth. This study provides, for the first time, important evidence of the sensory experience of the ocular surface in relation to the maturation of functional tear secretion during the postnatal period.
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U2 - 10.1016/j.ajpath.2019.05.015
DO - 10.1016/j.ajpath.2019.05.015
M3 - Article
C2 - 31220452
AN - SCOPUS:85070739185
SN - 0002-9440
VL - 189
SP - 1699
EP - 1710
JO - American Journal of Pathology
JF - American Journal of Pathology
IS - 9
ER -