Coronavirus disease 2019-associated rapidly progressive organizing pneumonia with fibrotic feature: Two case reports

Satoshi Okamori, Ho Lee, Yasushi Kondo, Yuto Akiyama, Hiroki Kabata, Yuko Kaneko, Makoto Ishii, Naoki Hasegawa, Koichi Fukunaga, Maya Saranathan

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)


Introduction:Pneumonia is one of the most important characteristics of coronavirus disease 2019 (COVID-19) and imaging findings of COVID-19 pneumonia are diverse and change over disease course. However, the detailed clinical course of organizing pneumonia (OP) caused by COVID-19 has not been clarified.Patient concerns:A 60-year-old man and a 61-year-old woman diagnosed with mild COVID-19 were admitted to our hospital. Their respiratory symptoms were deteriorating even after initiating treatment with antiviral drugs.Diagnosis:Chest X-rays and computed tomography scan showed a rapid progression of linear consolidation with reversed halo sign, distributed in subpleural and peri-bronchial regions. They also presented with pulmonary fibrosis findings, including traction bronchiectasis and marked lung volume reduction. They were diagnosed with rapidly progressing OP.Interventions:They were treated with systemic corticosteroids.Outcomes:The patients' imaging findings and respiratory conditions improved rapidly without any adverse effects.Conclusion:Physicians should carefully monitor patients with COVID-19, as they can develop rapidly progressive and fibrotic OP, which respond to corticosteroids.

Original languageEnglish
Pages (from-to)E21804
JournalMedicine (United States)
Issue number35
Publication statusPublished - 2020 Aug 28


  • coronavirus disease 2019
  • corticosteroids
  • organizing pneumonia

ASJC Scopus subject areas

  • General Medicine


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