Correlation between MIB-1 staining indices and recurrence in low-grade astrocytomas.

M. Hoshi, K. Yoshida, K. Shimazaki, H. Sasaki, M. Otani, T. Kawase

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16 Citations (Scopus)


Although low-grade astrocytomas are histologically benign, some of them recur frequently. We retrospectively investigated the relationship between MIB-1 staining index (SI) and recurrence in 47 low-grade astrocytomas that were treated in Keio University Hospital from 1981 to 1991. We found a correlation between SI and recurrence. MIB-1 SIs recurrent low-grade astrocytomas have been shown to be almost similar to those of astrocytoma grade 3. We concluded that it was very important to examine MIB-1 SI in all astrocytomas especially in low-grade astrocytomas, because MIB-1 SI is one of the factors from which we could predict-recurrence and decide whether radiotherapy or chemotherapy should be performed.

Original languageEnglish
Pages (from-to)47-51
Number of pages5
JournalBrain tumor pathology
Issue number1
Publication statusPublished - 1997
Externally publishedYes

ASJC Scopus subject areas

  • Oncology
  • Clinical Neurology
  • Cancer Research


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