Creation of pure nanodrugs and their anticancer properties

Hitoshi Kasai; Tatsuya Murakami; Yoshikazu Ikuta; Yoshitaka Koseki; Koichi Baba; Hidetoshi Oikawa; Hachiro Nakanishi; Masahiro Okada; Mitsuru Shoji; Minoru Ueda; Hiroshi Imahori; Mitsuru Hashida

doi:10.1002/anie.201204596

Creation of pure nanodrugs and their anticancer properties

Hitoshi Kasai, Tatsuya Murakami, Yoshikazu Ikuta, Yoshitaka Koseki, Koichi Baba, Hidetoshi Oikawa, Hachiro Nakanishi, Masahiro Okada, Mitsuru Shoji, Minoru Ueda, Hiroshi Imahori, Mitsuru Hashida

Research output: Contribution to journal › Article › peer-review

130 Citations (Scopus)

Abstract

A method for preparing nanoparticles of a water-insoluble drug that are suitable for administration to the human body has been established. A reprecipitation method was used to fabricate 50 nm nanoparticles of dimerized SN-38, an anticancer camptothecin derivative, that form stable aqueous dispersions and can penetrate into cancer cells to inhibit cell proliferation more potently than irinotecan.

Original language	English
Pages (from-to)	10315-10318
Number of pages	4
Journal	Angewandte Chemie - International Edition
Volume	51
Issue number	41
DOIs	https://doi.org/10.1002/anie.201204596
Publication status	Published - 2012 Oct 8
Externally published	Yes

Keywords

cancer
colloids
drug delivery
drug design
nanoparticles

ASJC Scopus subject areas

Catalysis
Chemistry(all)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/anie.201204596

Cite this

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TY - JOUR

T1 - Creation of pure nanodrugs and their anticancer properties

AU - Kasai, Hitoshi

AU - Murakami, Tatsuya

AU - Ikuta, Yoshikazu

AU - Koseki, Yoshitaka

AU - Baba, Koichi

AU - Oikawa, Hidetoshi

AU - Nakanishi, Hachiro

AU - Okada, Masahiro

AU - Shoji, Mitsuru

AU - Ueda, Minoru

AU - Imahori, Hiroshi

AU - Hashida, Mitsuru

PY - 2012/10/8

Y1 - 2012/10/8

N2 - A method for preparing nanoparticles of a water-insoluble drug that are suitable for administration to the human body has been established. A reprecipitation method was used to fabricate 50 nm nanoparticles of dimerized SN-38, an anticancer camptothecin derivative, that form stable aqueous dispersions and can penetrate into cancer cells to inhibit cell proliferation more potently than irinotecan.

AB - A method for preparing nanoparticles of a water-insoluble drug that are suitable for administration to the human body has been established. A reprecipitation method was used to fabricate 50 nm nanoparticles of dimerized SN-38, an anticancer camptothecin derivative, that form stable aqueous dispersions and can penetrate into cancer cells to inhibit cell proliferation more potently than irinotecan.

KW - cancer

KW - colloids

KW - drug delivery

KW - drug design

KW - nanoparticles

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JF - Angewandte Chemie - International Edition

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ER -

Creation of pure nanodrugs and their anticancer properties

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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