Cross-cultural traits for personality of patients with Parkinson's disease in Japan

Chieko Fujii, Shoji Harada, Norio Ohkoshi, Akito Hayashi, Kazuo Yoshizawa

Research output: Contribution to journalArticlepeer-review

46 Citations (Scopus)


Recent studies suggest that Parkinson's disease (PD) is associated with particular personality traits. Using Cloningers's Tridimensional Personality Questionnaire (TPQ), Menza and colleagues [1993: Neurology 43: 505-508] reported a possible association between PD and a reduced score in the novelty seeking (NS) dimension of the TPQ. We sought to determine whether this association, which was found in a study conducted in the United States, could also be found among Japanese PD patients. We performed personality assessments of 67 Japanese PD patients, using the TPQ test. The results suggest that Japanese PD patients have significantly lower scores in the NS dimension of the TPQ, as well as significantly higher harm avoidance (HA) scores, compared with matched control subjects. Furthermore, the PD patients undergoing treatment for depression using antidepressant drugs scored significantly higher in the HA dimension than PD patients who did not receive antidepressant drug treatment. Our results suggest that the high HA score, and the low NS score in the TPQ test observed in patients with PD, is a cross-cultural phenomenon, although the influence of depression, long-term treatment, and premorbid gene/environmental interactions may also affect these personality traits. (C) 2000 Wiley-Liss, Inc.

Original languageEnglish
Pages (from-to)1-3
Number of pages3
JournalAmerican Journal of Medical Genetics - Neuropsychiatric Genetics
Issue number1
Publication statusPublished - 2000 Feb 7
Externally publishedYes


  • Association
  • Cross-cultural phenomenon
  • Harm avoidance
  • Novelty seeking
  • Tridimensional Personality Questionnaire

ASJC Scopus subject areas

  • Genetics(clinical)
  • Psychiatry and Mental health
  • Cellular and Molecular Neuroscience


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