Current clinical perspective of urological oncology in the adolescent and young adult generation

Ryohei Takahashi, Hiroshi Asanuma, Ryuichi Mizuno, Mototsugu Oya

Research output: Contribution to journalReview articlepeer-review

1 Citation (Scopus)


Among adolescents and young adults, hematological tumors are the most common malignancies in younger patients; however, solid tumors also increase with advancing age. The pathogenesis of some of these tumors differs from that of tumors which develop in children, or middle-aged and older adults, and special care should be taken in their treatment and management. A treatment plan that takes into consideration future fertility is necessary for testicular tumors, and an educational campaign to encourage early detection is also essential. The treatment of adolescents with advanced testicular tumors should resemble therapeutic approaches for young adults and not a pediatric regimen. Adrenal tumors often develop as part of familiar hereditary syndrome. Therefore, taking the personal and family history is very important, and genetic counseling should be also recommended. In renal tumors, the incidence of translocation renal cell carcinomas is higher. Complete resection is the only promising method for long-term prognosis because of no established treatment for translocation renal cell carcinomas with distant metastasis. Bladder tumors are often detected by symptoms of gross hematuria and are found at a relatively early stage. Along with renal tumors, oncological evaluation including cystoscopy is also considered essential for gross hematuria. Wilms tumors and rhabdomyosarcomas could be managed in accordance with pediatric protocols to improve the treatment outcomes. The dedicated cancer survivorship care for adolescents and young adults could be also indispensable to conquer cancer and maintain a better quality of life.

Original languageEnglish
Pages (from-to)28-40
Number of pages13
JournalInternational Journal of Clinical Oncology
Issue number1
Publication statusPublished - 2023 Jan


  • Cancer survivorship
  • Familiar hereditary syndrome
  • Fertility
  • Germ cell tumor
  • Pheochromocytoma
  • Translocation renal cell carcinoma

ASJC Scopus subject areas

  • Surgery
  • Hematology
  • Oncology


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