Current topics in pheochromocytoma

K. Nakao; H. Itoh; K. Takaya

doi:10.1016/S0753-3322(00)80028-1

Current topics in pheochromocytoma

K. Nakao, H. Itoh, K. Takaya

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

Pheochromocytoma is the tumor that produces catecholamines and originates from chromaffin cells, which are differentiated from sympathoadrenal progenitor cells of neural crest under the influence of glucocorticoids. Genetic abnormalities of familial pheochromocytomas have elucidated oncogenic genetic bases of the tumor, including gene abnormalities of the RET proto-oncogene in multiple endocrine neoplasia type 2, VHL gene in von Hippel Lindau's disease or the NFI gene in neurofibromatosis. Co- localization of various substances with catecholamines in the tumor, including neuropeptide Y, opioid peptides or adrenomullin, which is the recently identified vasodepressor peptide elevating cAMP production, isrecognized. The significance of these substances in modulating clinical features of pheochromocytomas is not fully understood. (C) 2000 Editions scientifiques et medicales Elsevier SAS.

Original language	English
Pages (from-to)	124s-128s
Journal	Biomedicine and Pharmacotherapy
Volume	54
Issue number	SUPPL. 1
DOIs	https://doi.org/10.1016/S0753-3322(00)80028-1
Publication status	Published - 2000 Jun
Externally published	Yes

Keywords

Adrenal glands
Adrenomullin
Catecholamine
Hypertension
MEN
Neuropeptide Y
Oploid peptides
Pheochromocytoma
RET
Sympathetic nervous system
VHL gene

ASJC Scopus subject areas

Pharmacology

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10.1016/S0753-3322(00)80028-1

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title = "Current topics in pheochromocytoma",

abstract = "Pheochromocytoma is the tumor that produces catecholamines and originates from chromaffin cells, which are differentiated from sympathoadrenal progenitor cells of neural crest under the influence of glucocorticoids. Genetic abnormalities of familial pheochromocytomas have elucidated oncogenic genetic bases of the tumor, including gene abnormalities of the RET proto-oncogene in multiple endocrine neoplasia type 2, VHL gene in von Hippel Lindau's disease or the NFI gene in neurofibromatosis. Co- localization of various substances with catecholamines in the tumor, including neuropeptide Y, opioid peptides or adrenomullin, which is the recently identified vasodepressor peptide elevating cAMP production, isrecognized. The significance of these substances in modulating clinical features of pheochromocytomas is not fully understood. (C) 2000 Editions scientifiques et medicales Elsevier SAS.",

keywords = "Adrenal glands, Adrenomullin, Catecholamine, Hypertension, MEN, Neuropeptide Y, Oploid peptides, Pheochromocytoma, RET, Sympathetic nervous system, VHL gene",

author = "K. Nakao and H. Itoh and K. Takaya",

year = "2000",

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doi = "10.1016/S0753-3322(00)80028-1",

language = "English",

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journal = "Biomedicine and Pharmacotherapy",

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number = "SUPPL. 1",

}

TY - JOUR

T1 - Current topics in pheochromocytoma

AU - Nakao, K.

AU - Itoh, H.

AU - Takaya, K.

PY - 2000/6

Y1 - 2000/6

N2 - Pheochromocytoma is the tumor that produces catecholamines and originates from chromaffin cells, which are differentiated from sympathoadrenal progenitor cells of neural crest under the influence of glucocorticoids. Genetic abnormalities of familial pheochromocytomas have elucidated oncogenic genetic bases of the tumor, including gene abnormalities of the RET proto-oncogene in multiple endocrine neoplasia type 2, VHL gene in von Hippel Lindau's disease or the NFI gene in neurofibromatosis. Co- localization of various substances with catecholamines in the tumor, including neuropeptide Y, opioid peptides or adrenomullin, which is the recently identified vasodepressor peptide elevating cAMP production, isrecognized. The significance of these substances in modulating clinical features of pheochromocytomas is not fully understood. (C) 2000 Editions scientifiques et medicales Elsevier SAS.

AB - Pheochromocytoma is the tumor that produces catecholamines and originates from chromaffin cells, which are differentiated from sympathoadrenal progenitor cells of neural crest under the influence of glucocorticoids. Genetic abnormalities of familial pheochromocytomas have elucidated oncogenic genetic bases of the tumor, including gene abnormalities of the RET proto-oncogene in multiple endocrine neoplasia type 2, VHL gene in von Hippel Lindau's disease or the NFI gene in neurofibromatosis. Co- localization of various substances with catecholamines in the tumor, including neuropeptide Y, opioid peptides or adrenomullin, which is the recently identified vasodepressor peptide elevating cAMP production, isrecognized. The significance of these substances in modulating clinical features of pheochromocytomas is not fully understood. (C) 2000 Editions scientifiques et medicales Elsevier SAS.

KW - Adrenal glands

KW - Adrenomullin

KW - Catecholamine

KW - Hypertension

KW - MEN

KW - Neuropeptide Y

KW - Oploid peptides

KW - Pheochromocytoma

KW - RET

KW - Sympathetic nervous system

KW - VHL gene

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U2 - 10.1016/S0753-3322(00)80028-1

DO - 10.1016/S0753-3322(00)80028-1

M3 - Article

C2 - 10915008

AN - SCOPUS:0033917018

SN - 0753-3322

VL - 54

SP - 124s-128s

JO - Biomedicine and Pharmacotherapy

JF - Biomedicine and Pharmacotherapy

IS - SUPPL. 1

ER -

Current topics in pheochromocytoma

Abstract

Keywords

ASJC Scopus subject areas

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