Current View: Intestinal Stem Cells and Signaling

David H. Scoville, Toshiro Sato, Xi C. He, Linheng Li

Research output: Contribution to journalArticlepeer-review

343 Citations (Scopus)


Studies using mice have yielded significant amounts of information regarding signaling pathways, such as Wnt, bone morphogenic protein, PtdIns(3,4,5) kinase, and Notch, involved in intestinal development and homeostasis, including stem cell regulation and lineage specification and maturation. However, attempts to model signals definitively that control intestinal stem cells have been difficult because of a long-standing and recently reenergized debate surrounding their location. Although crypt-based columnar cells have been recently shown to display self-renewal and multipotential capacity, a large body of evidence supports long-term label-retaining cells, located on average at the +4 position just above the Paneth cells, as putative stem cells. Herein, we propose that both these cell types represent true intestinal stem cells maintained in different states (quiescent vs actively cycling), presumably via interactions with different microenvironments. Finally, we review current findings regarding the roles of Wnt, bone morphogenic protein, PtdIns(3,4,5) kinase, and Notch pathways within the intestine.

Original languageEnglish
Pages (from-to)849-864
Number of pages16
Issue number3
Publication statusPublished - 2008 Mar
Externally publishedYes

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology


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