TY - JOUR
T1 - Cycloaromatization and DNA cleavage of novel enyne-allene systems
AU - Toshima, Kazunobu
AU - Ohta, Kazumi
AU - Ohtsuka, Atsuo
AU - Matsumura, Shuichi
AU - Nakata, Masaya
PY - 1993/12/1
Y1 - 1993/12/1
N2 - The novel enyne-allene sulfones 5-8 were prepared by m-chloroperbenzoic acid oxidation of the corresponding enediyne sulfides 1-4; the enyne-allene sulfones 6-8 having a leaving group at the allylic position were aromatized by 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) via the allene-ene-cumulene intermediate 10 and showed DNA-cleaving activities under basic conditions without any additive.
AB - The novel enyne-allene sulfones 5-8 were prepared by m-chloroperbenzoic acid oxidation of the corresponding enediyne sulfides 1-4; the enyne-allene sulfones 6-8 having a leaving group at the allylic position were aromatized by 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) via the allene-ene-cumulene intermediate 10 and showed DNA-cleaving activities under basic conditions without any additive.
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U2 - 10.1039/C39930001406
DO - 10.1039/C39930001406
M3 - Article
AN - SCOPUS:0027437682
SN - 0022-4936
SP - 1406
EP - 1407
JO - Journal of the Chemical Society, Chemical Communications
JF - Journal of the Chemical Society, Chemical Communications
IS - 18
ER -