Cystic Pineocytoma Successfully Treated with Synchronized Chemoradiotherapy: Case Report

Masashi Nakatsukasa, Shigeo Toya, Mitsuhiro Otani, Kazunari Yoshida, Yoshiyuki Ishida, Yoshihiro Ogawa

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4 Citations (Scopus)


A case of pineocytoma associated with intraventricular and meningeal metastasis is reported. The patient, a 25-year-old female, was admitted complaining of headache. Computed tomography revealed an irregular-shaped pineal lesion enhanced by contrast medium and accompanied by a cyst. An intraventricular cystic metastatic lesion and meningeal metastasis were also suggested. Biopsy of the pineal region proved the lesion to be a pineocytoma without neuronal or filial differentiation. Ventriculoperitoneal shunting was performed, and radiation therapy combined with chemotherapy (ACNU and vincristine) was administered. This treatment apparently destroyed both the primary and metastatic lesions, and the patient returned to her normal life. In 4 years of follow-up there has been no recurrence of the tumor. Pineocytoma with meningeal metastasis usually has a poor prognosis, but in this case combined radiation therapy and chemotherapy was curative. Although pineocytoma is rarely accompanied by a cyst, in cases of a pineal lesion coexistent with a cyst, a diagnosis of pineocytoma should be considered.

Original languageEnglish
Pages (from-to)333-337
Number of pages5
JournalNeurologia medico-chirurgica
Issue number4
Publication statusPublished - 1989


  • chemotherapy
  • computed tomography
  • meningeal metastasis
  • pineocytoma
  • radiation therapy

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology


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