Abstract
Composition and inducibility of cytochrome P450 (CYP) in ocular tissues were investigated using reverse transcription-polymerase chain reaction (RT-PCR) and immunoblot techniques. Composition of ocular CYPs is more restricted than that of hepatic forms. High levels of CYP2B1/2 and reduced levels of CYP2C11 expression were detected in rat ocular tissues. Phenobarbital induced CYP2B1/2 expression in the lens but not in the rest of the eye, whereas CYP2C11 induction was observed in both regions. In addition, CYP2B1/2 proteins were found to be prominent in the retina. Our data indicate eye-specific regulation of CYP expression.
| Original language | English |
|---|---|
| Pages (from-to) | 346-349 |
| Number of pages | 4 |
| Journal | Journal of Health Science |
| Volume | 48 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - 2002 Aug |
| Externally published | Yes |
Keywords
- Cytochrome P450
- Lens
- Ocular tissue
ASJC Scopus subject areas
- Toxicology
- Health, Toxicology and Mutagenesis