Cytotoxic substances from two species of Japanese sea hares: Chemistry and bioactivity

Kiyoyuki Yamada; Makoto Ojika; Hideo Kigoshi; Kiyotake Suenaga

doi:10.2183/pjab.86.176

Cytotoxic substances from two species of Japanese sea hares: Chemistry and bioactivity

Kiyoyuki Yamada, Makoto Ojika, Hideo Kigoshi, Kiyotake Suenaga

Department of Chemistry

Research output: Contribution to journal › Review article › peer-review

23 Citations (Scopus)

Abstract

From the sea hares belonging to two genera, Aplysia and Dolabella, a variety of new cytotoxic substances were isolated as minute constituents: their chemical structures were determined and their cytotoxicity was evaluated. Regarding the highly cytotoxic substances, further chemical and biological studies were performed that included their asymmetric chemical synthesis and elucidation of biological characteristics such as antitumor activity.

Original language	English
Pages (from-to)	176-189
Number of pages	14
Journal	Proceedings of the Japan Academy Series B: Physical and Biological Sciences
Volume	86
Issue number	3
DOIs	https://doi.org/10.2183/pjab.86.176
Publication status	Published - 2010 Mar

Keywords

Antitumor activity
Chemical structure
Chemical synthesis
Cytotoxic substances
Isolation
Sea hare

ASJC Scopus subject areas

Agricultural and Biological Sciences(all)
Physics and Astronomy(all)

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abstract = "From the sea hares belonging to two genera, Aplysia and Dolabella, a variety of new cytotoxic substances were isolated as minute constituents: their chemical structures were determined and their cytotoxicity was evaluated. Regarding the highly cytotoxic substances, further chemical and biological studies were performed that included their asymmetric chemical synthesis and elucidation of biological characteristics such as antitumor activity.",

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AU - Yamada, Kiyoyuki

AU - Ojika, Makoto

AU - Kigoshi, Hideo

AU - Suenaga, Kiyotake

PY - 2010/3

Y1 - 2010/3

N2 - From the sea hares belonging to two genera, Aplysia and Dolabella, a variety of new cytotoxic substances were isolated as minute constituents: their chemical structures were determined and their cytotoxicity was evaluated. Regarding the highly cytotoxic substances, further chemical and biological studies were performed that included their asymmetric chemical synthesis and elucidation of biological characteristics such as antitumor activity.

AB - From the sea hares belonging to two genera, Aplysia and Dolabella, a variety of new cytotoxic substances were isolated as minute constituents: their chemical structures were determined and their cytotoxicity was evaluated. Regarding the highly cytotoxic substances, further chemical and biological studies were performed that included their asymmetric chemical synthesis and elucidation of biological characteristics such as antitumor activity.

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KW - Chemical structure

KW - Chemical synthesis

KW - Cytotoxic substances

KW - Isolation

KW - Sea hare

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JO - Proceedings of the Japan Academy Series B: Physical and Biological Sciences

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Cytotoxic substances from two species of Japanese sea hares: Chemistry and bioactivity

Abstract

Keywords

ASJC Scopus subject areas

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