Cytotoxicity of estradiol, equilin, equilenin, and their derivatives on Chinese hamster V79 cells

Taiko Oda; Noriko Ikeda; Shoko Nakashima; Yoshihiro Sato

doi:10.1081/DCT-100108473

Cytotoxicity of estradiol, equilin, equilenin, and their derivatives on Chinese hamster V79 cells

Taiko Oda, Noriko Ikeda, Shoko Nakashima, Yoshihiro Sato

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

Recently, we investigated the inhibitory effects of 17β-estradiol and diethylstilbestrol on microtubule assembly, cytotoxicity, and aneuploidy in V79 cells. The present study analyzes the effects of equilin and equilenin (amongst the natural estrogens originally isolated from the urine of pregnant horses) and their related compounds, on the relative plating efficiency of Chinese hamster V79 cells. The results showed that a hydroxyl group on 17-C and a methoxyl group on 3-C of the estrogen skeleton were important for cytotoxicity. Of the various compounds analyzed, 2-methoxyestradiol had the strongest cytotoxicity, suggesting also the importance of a methoxyl group on 2-C.

Original language	English
Pages (from-to)	75-82
Number of pages	8
Journal	Drug and Chemical Toxicology
Volume	25
Issue number	1
DOIs	https://doi.org/10.1081/DCT-100108473
Publication status	Published - 2002
Externally published	Yes

ASJC Scopus subject areas

Public Health, Environmental and Occupational Health
Health, Toxicology and Mutagenesis
Toxicology
Chemical Health and Safety
Pharmacology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1081/DCT-100108473

Cite this

@article{540acaabf0f24c91bbbc46b4fdcf8fab,

title = "Cytotoxicity of estradiol, equilin, equilenin, and their derivatives on Chinese hamster V79 cells",

abstract = "Recently, we investigated the inhibitory effects of 17β-estradiol and diethylstilbestrol on microtubule assembly, cytotoxicity, and aneuploidy in V79 cells. The present study analyzes the effects of equilin and equilenin (amongst the natural estrogens originally isolated from the urine of pregnant horses) and their related compounds, on the relative plating efficiency of Chinese hamster V79 cells. The results showed that a hydroxyl group on 17-C and a methoxyl group on 3-C of the estrogen skeleton were important for cytotoxicity. Of the various compounds analyzed, 2-methoxyestradiol had the strongest cytotoxicity, suggesting also the importance of a methoxyl group on 2-C.",

author = "Taiko Oda and Noriko Ikeda and Shoko Nakashima and Yoshihiro Sato",

year = "2002",

doi = "10.1081/DCT-100108473",

language = "English",

volume = "25",

pages = "75--82",

journal = "Drug and Chemical Toxicology",

issn = "0148-0545",

publisher = "Informa Healthcare",

number = "1",

}

TY - JOUR

T1 - Cytotoxicity of estradiol, equilin, equilenin, and their derivatives on Chinese hamster V79 cells

AU - Oda, Taiko

AU - Ikeda, Noriko

AU - Nakashima, Shoko

AU - Sato, Yoshihiro

PY - 2002

Y1 - 2002

N2 - Recently, we investigated the inhibitory effects of 17β-estradiol and diethylstilbestrol on microtubule assembly, cytotoxicity, and aneuploidy in V79 cells. The present study analyzes the effects of equilin and equilenin (amongst the natural estrogens originally isolated from the urine of pregnant horses) and their related compounds, on the relative plating efficiency of Chinese hamster V79 cells. The results showed that a hydroxyl group on 17-C and a methoxyl group on 3-C of the estrogen skeleton were important for cytotoxicity. Of the various compounds analyzed, 2-methoxyestradiol had the strongest cytotoxicity, suggesting also the importance of a methoxyl group on 2-C.

AB - Recently, we investigated the inhibitory effects of 17β-estradiol and diethylstilbestrol on microtubule assembly, cytotoxicity, and aneuploidy in V79 cells. The present study analyzes the effects of equilin and equilenin (amongst the natural estrogens originally isolated from the urine of pregnant horses) and their related compounds, on the relative plating efficiency of Chinese hamster V79 cells. The results showed that a hydroxyl group on 17-C and a methoxyl group on 3-C of the estrogen skeleton were important for cytotoxicity. Of the various compounds analyzed, 2-methoxyestradiol had the strongest cytotoxicity, suggesting also the importance of a methoxyl group on 2-C.

UR - http://www.scopus.com/inward/record.url?scp=0036166267&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036166267&partnerID=8YFLogxK

U2 - 10.1081/DCT-100108473

DO - 10.1081/DCT-100108473

M3 - Article

C2 - 11850971

AN - SCOPUS:0036166267

SN - 0148-0545

VL - 25

SP - 75

EP - 82

JO - Drug and Chemical Toxicology

JF - Drug and Chemical Toxicology

IS - 1

ER -

Cytotoxicity of estradiol, equilin, equilenin, and their derivatives on Chinese hamster V79 cells

Abstract

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this