TY - JOUR
T1 - Daily inhalation of hydrogen gas has a blood pressure-lowering effect in a rat model of hypertension
AU - Sugai, Kazuhisa
AU - Tamura, Tomoyoshi
AU - Sano, Motoaki
AU - Uemura, Shizuka
AU - Fujisawa, Masahiko
AU - Katsumata, Yoshinori
AU - Endo, Jin
AU - Yoshizawa, Joe
AU - Homma, Koichiro
AU - Suzuki, Masaru
AU - Kobayashi, Eiji
AU - Sasaki, Junichi
AU - Hakamata, Yoji
N1 - Funding Information:
This study was supported by the Japan Society for the Promotion of Science (KAKENHI [Number: 16K11420]) (M. Suzuki) and a research grant from Taiyo Nippon Sanso Corporation (no identifiable grant number) (M. Sano). The funders had no role in the study design, data collection, analysis, writing of the manuscript, or the decision to submit the manuscript for publication.
Publisher Copyright:
© 2020, The Author(s).
PY - 2020/12
Y1 - 2020/12
N2 - A recent clinical study demonstrated that haemodialysis with a dialysate containing hydrogen (H2) improves blood pressure control in end-stage kidney disease. Herein, we examined whether H2 has a salutary effect on hypertension in animal models. We subjected 5/6 nephrectomised rats to inhalation of either H2 (1.3% H2 + 21% O2 + 77.7% N2) or control (21% O2 + 79% N2) gas mixture for 1 h per day. H2 significantly suppressed increases in blood pressure after 5/6 nephrectomy. The anti-hypertensive effect of H2 was also confirmed in rats in a stable hypertensive state 3 weeks after nephrectomy. To examine the detailed effects of H2 on hypertension, we used an implanted telemetry system to continuously monitor blood pressure. H2 exerted an anti-hypertensive effect not only during daytime rest, but also during night-time activities. Spectral analysis of blood pressure variability revealed that H2 improved autonomic imbalance, namely by suppressing the overly active sympathetic nervous system and augmenting parasympathetic nervous system activity; these effects co-occurred with the blood pressure-lowering effect. In conclusion, 1-h daily exposure to H2 exerts an anti-hypertensive effect in an animal model of hypertension.
AB - A recent clinical study demonstrated that haemodialysis with a dialysate containing hydrogen (H2) improves blood pressure control in end-stage kidney disease. Herein, we examined whether H2 has a salutary effect on hypertension in animal models. We subjected 5/6 nephrectomised rats to inhalation of either H2 (1.3% H2 + 21% O2 + 77.7% N2) or control (21% O2 + 79% N2) gas mixture for 1 h per day. H2 significantly suppressed increases in blood pressure after 5/6 nephrectomy. The anti-hypertensive effect of H2 was also confirmed in rats in a stable hypertensive state 3 weeks after nephrectomy. To examine the detailed effects of H2 on hypertension, we used an implanted telemetry system to continuously monitor blood pressure. H2 exerted an anti-hypertensive effect not only during daytime rest, but also during night-time activities. Spectral analysis of blood pressure variability revealed that H2 improved autonomic imbalance, namely by suppressing the overly active sympathetic nervous system and augmenting parasympathetic nervous system activity; these effects co-occurred with the blood pressure-lowering effect. In conclusion, 1-h daily exposure to H2 exerts an anti-hypertensive effect in an animal model of hypertension.
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U2 - 10.1038/s41598-020-77349-8
DO - 10.1038/s41598-020-77349-8
M3 - Article
C2 - 33244027
AN - SCOPUS:85096664219
SN - 2045-2322
VL - 10
JO - Scientific reports
JF - Scientific reports
IS - 1
M1 - 20173
ER -