Day-to-day variability in home blood pressure is associated with cognitive decline: The ohasama study

Akihiro Matsumoto, Michihiro Satoh, Masahiro Kikuya, Takayoshi Ohkubo, Mikio Hirano, Ryusuke Inoue, Takanao Hashimoto, Azusa Hara, Takuo Hirose, Taku Obara, Hirohito Metoki, Kei Asayama, Aya Hosokawa, Kazuhito Totsune, Haruhisa Hoshi, Toru Hosokawa, Hiroshi Sato, Yutaka Imai

Research output: Contribution to journalArticlepeer-review

67 Citations (Scopus)


Although an association between high blood pressure and cognitive decline has been reported, no studies have investigated the association between home blood pressure and cognitive decline. Home blood pressure measurements can also provide day-to-day blood pressure variability calculated as the within-participant SD. The objectives of this prospective study were to clarify whether home blood pressure has a stronger predictive power for cognitive decline than conventional blood pressure and to compare the predictive power of the averaged home blood pressure with day-to-day home blood pressure variability for cognitive decline. Of 485 participants (mean age, 63 years) who did not have cognitive decline (defined as Mini-Mental State Examination score, <24) initially, 46 developed cognitive decline after a median follow-up of 7.8 years. Each 1-SD increase in the home systolic blood pressure value showed a significant association with cognitive decline (odds ratio, 1.48; P=0.03). However, conventional systolic blood pressure was not significantly associated with cognitive decline (odds ratio, 1.24; P=0.2). The day-to-day variability in systolic blood pressure was significantly associated with cognitive decline after including home systolic blood pressure in the same model (odds ratio, 1.51; P=0.02), whereas the odds ratio of home systolic blood pressure remained positive, but it was not significant. Home blood pressure measurements can be useful for predicting future cognitive decline because they can provide information not only on blood pressure values but also on day-to-day blood pressure variability.

Original languageEnglish
Pages (from-to)1333-1338
Number of pages6
Issue number6
Publication statusPublished - 2014 Jun
Externally publishedYes


  • Blood pressure
  • Cohort studies
  • Mild cognitive impairment

ASJC Scopus subject areas

  • Internal Medicine


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