TY - JOUR
T1 - De novo CD5+ diffuse large B cell lymphoma with basophilia in the peripheral blood
T2 - Successful treatment with autologous peripheral blood stem cell transplantation
AU - Tokuhira, Michihide
AU - Watanabe, Reiko
AU - Iizuka, Atsushi
AU - Sekiguchi, Yasunobu
AU - Nemoto, Tomoe
AU - Hanzawa, Kyoto
AU - Takamatsu, Ichiro
AU - Maruyama, Taro
AU - Tamaru, Jun Ichi
AU - Itoyama, Shinji
AU - Suzuki, Hiroshi
AU - Takeuchi, Tsutomu
AU - Mori, Shigehisa
PY - 2007/2
Y1 - 2007/2
N2 - Basophils play an important role in allergic inflammation and are pathologically related to hematological disturbances, such as iron deficiency anemia and myeloproliferative disorders; however, they are only rarely encountered in lymphoid malignancies. Here, we report the case of a 33-year-old man with a bulky mass of the small intestine, multiple paraaortic lymphoadenopathy, pleural effusion, and ascites, who was diagnosed as a case of de novo CD5+ diffuse large B cell lymphoma (DLBCL). This patient showed a marked elevation of the basophil count in the peripheral blood, which appeared to run in parallel with the tumor burden. High dose chemotherapy followed by autologous peripheral blood cell transplantation yielded complete remission, and the patient has remained disease free for 5 years. To the best of our knowledge, this is the first report of a case of de novo CD5+ DLBCL showing marked elevation of the PB basophil count.
AB - Basophils play an important role in allergic inflammation and are pathologically related to hematological disturbances, such as iron deficiency anemia and myeloproliferative disorders; however, they are only rarely encountered in lymphoid malignancies. Here, we report the case of a 33-year-old man with a bulky mass of the small intestine, multiple paraaortic lymphoadenopathy, pleural effusion, and ascites, who was diagnosed as a case of de novo CD5+ diffuse large B cell lymphoma (DLBCL). This patient showed a marked elevation of the basophil count in the peripheral blood, which appeared to run in parallel with the tumor burden. High dose chemotherapy followed by autologous peripheral blood cell transplantation yielded complete remission, and the patient has remained disease free for 5 years. To the best of our knowledge, this is the first report of a case of de novo CD5+ DLBCL showing marked elevation of the PB basophil count.
KW - Autologous peripheral blood stem cell transplantation
KW - Basophilia
KW - CD5
KW - Diffuse large B cell lymphoma
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U2 - 10.1002/ajh.20786
DO - 10.1002/ajh.20786
M3 - Article
C2 - 17019691
AN - SCOPUS:33846497904
SN - 0361-8609
VL - 82
SP - 162
EP - 167
JO - American journal of hematology
JF - American journal of hematology
IS - 2
ER -