Decrease in corneal sensitivity and change in tear function in dry eye

Ke Ping Xu, Yukiko Yagi, Kazuo Tsubota

Research output: Contribution to journalArticlepeer-review

178 Citations (Scopus)


Our purpose was to investigate the relationship between insufficient tear secretion and decreased corneal sensitivity. We studied 59 patients with dry eye, 15 of whom had Sjogren's syndrome (SS), and 26 healthy subjects. Corneal sensitivity was measured by the esthesiometer of Cochet and Bonnet. Schirmer test with or without anesthesia, tear clearance rate, tear function index, and rose bengal and fluorescein staining were also evaluated. The mean corneal sensitivity of either dry-eye group (4.6±1.2 and 4.5±1.2 cm for non-SS and SS dry eye, respectively) was significantly lower than that of the control (5.8±0.4 cm, p < 0.001). Corneal sensitivity correlated significantly with the Schirmer values with anesthesia and the tear function index in the two dry-eye groups and the control (p < 0.05). There were significant relationships between corneal sensitivity and the rose bengal and fluorescein scores in the three groups (p < 0.05). Hyposecretion of tears in dry eye may lead to pathologic changes in corneal epithelium and a decline in corneal sensitivity. Prompt treatment of dry eye is essential to maintain a normal corneal protective mechanism.

Original languageEnglish
Pages (from-to)235-239
Number of pages5
Issue number3
Publication statusPublished - 1996 Apr 29
Externally publishedYes


  • Corneal sensitivity
  • Dry eye
  • Tear function parameter

ASJC Scopus subject areas

  • Ophthalmology


Dive into the research topics of 'Decrease in corneal sensitivity and change in tear function in dry eye'. Together they form a unique fingerprint.

Cite this