@article{dc2b45f3ffcf477d9501317b61a1246b,
title = "Decreased KAT5 Expression Impairs DNA Repair and Induces Altered DNA Methylation in Kidney Podocytes",
abstract = "Hishikawa et al. reveal that KAT5-mediated DNA repair is essential for podocyte maintenance and is related to changes in DNA methylation status. Decreased podocyte KAT5 expression may contribute to the pathophysiology of diabetic nephropathy, suggesting a therapeutic target.",
keywords = "DNA damage repair, DNA methylation, diabetic nephropathy, podocyte",
author = "Akihito Hishikawa and Kaori Hayashi and Takaya Abe and Mari Kaneko and Hideki Yokoi and Tatsuhiko Azegami and Mari Nakamura and Norifumi Yoshimoto and Takeshi Kanda and Yusuke Sakamaki and Hiroshi Itoh",
note = "Funding Information: We gratefully acknowledge Dr. P. Chambon for providing the Cre ER T2 plasmid, Dr. Moin A. Saleem for the human podocyte cell line, and Dr. K. Kohno for providing a plasmid containing the KAT5 promoter region. This study was supported by Grants for Scientific Research (25860687 and 16K19496) from the Ministry of Education, Culture, Sports, Science and Technology (MEXT) of Japan; Keio University Research Grants for Life Science and Medicine; a grant from Banyu Life Science Foundation International ; the Ishibashi Yukiko Memorial Foundation ; the Japan Medical Woman{\textquoteright}s Association ; the Japanese Association of Dialysis Physicians ; the Asahi Life Foundation ; the Takeda Science Foundation ; and the Daiwa Securities Health Foundation in Tokyo, Japan. A.H. was supported by the Keio University Doctorate Student Grant-in-Aid Program and a Grant-in-Aid for JSPS Fellows ( 201813428 ). Funding Information: We gratefully acknowledge Dr. P. Chambon for providing the Cre ERT2 plasmid, Dr. Moin A. Saleem for the human podocyte cell line, and Dr. K. Kohno for providing a plasmid containing the KAT5 promoter region. This study was supported by Grants for Scientific Research (25860687 and 16K19496) from the Ministry of Education, Culture, Sports, Science and Technology (MEXT) of Japan; Keio University Research Grants for Life Science and Medicine; a grant from Banyu Life Science Foundation International; the Ishibashi Yukiko Memorial Foundation; the Japan Medical Woman's Association; the Japanese Association of Dialysis Physicians; the Asahi Life Foundation; the Takeda Science Foundation; and the Daiwa Securities Health Foundation in Tokyo, Japan. A.H. was supported by the Keio University Doctorate Student Grant-in-Aid Program and a Grant-in-Aid for JSPS Fellows (201813428). Publisher Copyright: {\textcopyright} 2019 The Author(s)",
year = "2019",
month = jan,
day = "29",
doi = "10.1016/j.celrep.2019.01.005",
language = "English",
volume = "26",
pages = "1318--1332.e4",
journal = "Cell Reports",
issn = "2211-1247",
publisher = "Cell Press",
number = "5",
}
