Decreased KAT5 Expression Impairs DNA Repair and Induces Altered DNA Methylation in Kidney Podocytes

Akihito Hishikawa; Kaori Hayashi; Takaya Abe; Mari Kaneko; Hideki Yokoi; Tatsuhiko Azegami; Mari Nakamura; Norifumi Yoshimoto; Takeshi Kanda; Yusuke Sakamaki; Hiroshi Itoh

doi:10.1016/j.celrep.2019.01.005

Decreased KAT5 Expression Impairs DNA Repair and Induces Altered DNA Methylation in Kidney Podocytes

Akihito Hishikawa
, Kaori Hayashi
, Takaya Abe
, Mari Kaneko
, Hideki Yokoi
, Tatsuhiko Azegami
, Mari Nakamura
, Norifumi Yoshimoto
, Takeshi Kanda
, Yusuke Sakamaki
, Hiroshi Itoh

Research output: Contribution to journal › Article › peer-review

35 Citations (Scopus)

Abstract

Hishikawa et al. reveal that KAT5-mediated DNA repair is essential for podocyte maintenance and is related to changes in DNA methylation status. Decreased podocyte KAT5 expression may contribute to the pathophysiology of diabetic nephropathy, suggesting a therapeutic target.

Original language	English
Pages (from-to)	1318-1332.e4
Journal	Cell Reports
Volume	26
Issue number	5
DOIs	https://doi.org/10.1016/j.celrep.2019.01.005
Publication status	Published - 2019 Jan 29

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

DNA damage repair
DNA methylation
diabetic nephropathy
podocyte

ASJC Scopus subject areas

General Biochemistry,Genetics and Molecular Biology

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10.1016/j.celrep.2019.01.005

Cite this

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title = "Decreased KAT5 Expression Impairs DNA Repair and Induces Altered DNA Methylation in Kidney Podocytes",

abstract = "Hishikawa et al. reveal that KAT5-mediated DNA repair is essential for podocyte maintenance and is related to changes in DNA methylation status. Decreased podocyte KAT5 expression may contribute to the pathophysiology of diabetic nephropathy, suggesting a therapeutic target.",

keywords = "DNA damage repair, DNA methylation, diabetic nephropathy, podocyte",

author = "Akihito Hishikawa and Kaori Hayashi and Takaya Abe and Mari Kaneko and Hideki Yokoi and Tatsuhiko Azegami and Mari Nakamura and Norifumi Yoshimoto and Takeshi Kanda and Yusuke Sakamaki and Hiroshi Itoh",

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year = "2019",

month = jan,

day = "29",

doi = "10.1016/j.celrep.2019.01.005",

language = "English",

volume = "26",

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TY - JOUR

T1 - Decreased KAT5 Expression Impairs DNA Repair and Induces Altered DNA Methylation in Kidney Podocytes

AU - Hishikawa, Akihito

AU - Hayashi, Kaori

AU - Abe, Takaya

AU - Kaneko, Mari

AU - Yokoi, Hideki

AU - Azegami, Tatsuhiko

AU - Nakamura, Mari

AU - Yoshimoto, Norifumi

AU - Kanda, Takeshi

AU - Sakamaki, Yusuke

AU - Itoh, Hiroshi

PY - 2019/1/29

Y1 - 2019/1/29

N2 - Hishikawa et al. reveal that KAT5-mediated DNA repair is essential for podocyte maintenance and is related to changes in DNA methylation status. Decreased podocyte KAT5 expression may contribute to the pathophysiology of diabetic nephropathy, suggesting a therapeutic target.

AB - Hishikawa et al. reveal that KAT5-mediated DNA repair is essential for podocyte maintenance and is related to changes in DNA methylation status. Decreased podocyte KAT5 expression may contribute to the pathophysiology of diabetic nephropathy, suggesting a therapeutic target.

KW - DNA damage repair

KW - DNA methylation

KW - diabetic nephropathy

KW - podocyte

UR - https://www.scopus.com/pages/publications/85060081146

UR - https://www.scopus.com/pages/publications/85060081146#tab=citedBy

U2 - 10.1016/j.celrep.2019.01.005

DO - 10.1016/j.celrep.2019.01.005

M3 - Article

C2 - 30699357

AN - SCOPUS:85060081146

SN - 2211-1247

VL - 26

SP - 1318-1332.e4

JO - Cell Reports

JF - Cell Reports

IS - 5

ER -

Decreased KAT5 Expression Impairs DNA Repair and Induces Altered DNA Methylation in Kidney Podocytes

Abstract

UN SDGs

Keywords

ASJC Scopus subject areas

Access to Document

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