Deep lamellar keratoplasty in severe ocular surface disease

Shigeto Shimmura, Akiko Higa, Masahiro Omoto, Jun Shimazaki, Kazuo Tsubota

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


PURPOSE: To demonstrate the efficacy and safety of deep lamellar keratoplasty(DLKP) in the treatment of corneal opacity in severe ocular surface disease. METHODS: A total of 12 eyes of 11 patients were analyzed in this retrospective case series. The original diseases were Stevens Johnson syndrome (SJS : 3 eyes), ocular ciccatricial pemphigoid(OCP : 2 eyes), thermal burns (2 eyes), limbal deficiency due to unknown cause (2 eyes), and corneal scarring due to trachoma (3 eyes). Cases with total limbal deficiency (6 eyes) were also treated with secondary or simultaneous limbal transplantation. Cataract surgery was also performed in 4 eyes following DLKP. RESULTS: DLKP was successfully done in all cases. One case with SJS experienced an immunological rejection against the limbal graft. Two eyes with SJS eventually developed ulcers that required therapeutic penefrating keratoplasty. Visual improvement was observed in 9 out of 12 eyes, of which 2 cases maintained a corrected visual acuity of 0.1 despite conjunctivalization of the ocular surface. CONCLUSION: DLKP is an effective means to treat stromal opacity in patients with ocular surface disease.

Original languageEnglish
Pages (from-to)391-396
Number of pages6
JournalNippon Ganka Gakkai zasshi
Issue number5
Publication statusPublished - 2007 May

ASJC Scopus subject areas

  • Medicine(all)


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