@article{66a6a7ef82c141b7bff5cd1106aedc27,
title = "Degradation of type IX collagen by matrix metalloproteinase 3 (stromelysin) from human rheumatoid synovial cells",
abstract = "The degradation of type IX collagen, a minor collagen in cartilage, was examined by treatment with three different types of matrix metalloproteinases (MMPs) purified from the culture medium of rheumatoid synovial cells. Neither MMP-1 (collagenase) nor MMP-2 (so-called 'gelatinase') could digest type IX collagen, but MMP-3 (stromelysin) readily degraded it into smaller fragments. This suggests that MMP-3 may be responsible for the pathological degradation and/or normal turnover of type IX collagen.",
keywords = "Degradation, Extracellular matrix, Proteinase",
author = "Yasunori Okada and Hiroshi Konomi and Toshikazu Yada and Koji Kimata and Hideaki Nagase",
note = "Funding Information: AcknowledgementWs:e areg ratefult o Dr Joan K. Heatho f the Departmenot f Bone Biology and OsteoporosisM, erck, Sharp and DohmeR esearchL aboratoriesW, estP oint, PA, for critical readingo f this manuscriptW. e also wish to thank Dr Sakaru Suzuki of the Departmento f Chemistry,F aculty of Science, NagoyaU niversity,a nd Dr Isao Nakanishio f the Department of Pathology, School of Medicine, KanazawaU niversityfor their encouragemenotf this study.T his work was supportedin part by Grant-in-Aid (63570142fr)o m the Ministry of Education, Sciencea ndC ultureo f Japan and UeharaM emorialF oun-dation to Y.O., and by Grant AR 39189f rom the National Instituteso f Health to H.N.",
year = "1989",
month = feb,
day = "27",
doi = "10.1016/0014-5793(89)80586-1",
language = "English",
volume = "244",
pages = "473--476",
journal = "FEBS Letters",
issn = "0014-5793",
publisher = "Elsevier",
number = "2",
}