TY - JOUR
T1 - Degree centrality and fractional amplitude of low-frequency oscillations associated with Stroop interference
AU - Takeuchi, Hikaru
AU - Taki, Yasuyuki
AU - Nouchi, Rui
AU - Sekiguchi, Atsushi
AU - Hashizume, Hiroshi
AU - Sassa, Yuko
AU - Kotozaki, Yuka
AU - Miyauchi, Carlos Makoto
AU - Yokoyama, Ryoichi
AU - Iizuka, Kunio
AU - Nakagawa, Seishu
AU - Nagase, Tomomi
AU - Kunitoki, Keiko
AU - Kawashima, Ryuta
N1 - Funding Information:
We thank Yuki Yamada for operating the MRI scanner, Haruka Nouchi for conducting the psychological tests, the other assistants who helped with the experiments and the study, and the participants and all our other colleagues at IDAC, Tohoku University for their support. This study was supported by JST/RISTEX , JST/CREST , and a Grant-in-Aid for Young Scientists (B) (KAKENHI 23700306 ) and Young Scientists (A) (KAKENHI 25700012 ) from the Ministry of Education, Culture, Sports, Science, and Technology .
Publisher Copyright:
© 2015 Elsevier Inc.
PY - 2015/10/1
Y1 - 2015/10/1
N2 - Stroop paradigms are commonly used as an index of attention deficits and a tool for investigating functions of the frontal lobes and other associated structures. Here we investigated the correlation between resting-state functional magnetic imaging (fMRI) measures [degree centrality (DC)/fractional amplitude of low frequency fluctuations (fALFFs)] and Stroop interference. We examined this relationship in the brains of 958 healthy young adults. DC reflects the number of instantaneous functional connections between a region and the rest of the brain within the entire connectivity matrix of the brain (connectome), and thus how much of the node influences the entire brain areas, while fALFF is an indicator of the intensity of regional brain spontaneous activity. Reduced Stroop interference was associated with larger DC in the left lateral prefrontal cortex, left IFJ, and left inferior parietal lobule as well as larger fALFF in the areas of the dorsal attention network and the precuneus. These findings suggest that Stroop performance is reflected in resting state functional properties of these areas and the network. In addition, default brain activity of the dorsal attention network and precuneus as well as higher cognitive processes represented there, and default stronger global influence of the areas critical in executive functioning underlie better Stroop performance.
AB - Stroop paradigms are commonly used as an index of attention deficits and a tool for investigating functions of the frontal lobes and other associated structures. Here we investigated the correlation between resting-state functional magnetic imaging (fMRI) measures [degree centrality (DC)/fractional amplitude of low frequency fluctuations (fALFFs)] and Stroop interference. We examined this relationship in the brains of 958 healthy young adults. DC reflects the number of instantaneous functional connections between a region and the rest of the brain within the entire connectivity matrix of the brain (connectome), and thus how much of the node influences the entire brain areas, while fALFF is an indicator of the intensity of regional brain spontaneous activity. Reduced Stroop interference was associated with larger DC in the left lateral prefrontal cortex, left IFJ, and left inferior parietal lobule as well as larger fALFF in the areas of the dorsal attention network and the precuneus. These findings suggest that Stroop performance is reflected in resting state functional properties of these areas and the network. In addition, default brain activity of the dorsal attention network and precuneus as well as higher cognitive processes represented there, and default stronger global influence of the areas critical in executive functioning underlie better Stroop performance.
KW - Amplitude of low-frequency fluctuations
KW - Degree centrality
KW - Dorsolateral prefrontal cortex
KW - Inferior frontal junction
KW - Resting state
KW - Stroop interference
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U2 - 10.1016/j.neuroimage.2015.06.058
DO - 10.1016/j.neuroimage.2015.06.058
M3 - Article
C2 - 26123381
AN - SCOPUS:84937203814
SN - 1053-8119
VL - 119
SP - 197
EP - 209
JO - NeuroImage
JF - NeuroImage
ER -