Dendropanax morbiferus leaf extract facilitates oligodendrocyte development

Ji Young Kim, Ju Young Yoon, Yuki Sugiura, Soo Kyoung Lee, Jae Don Park, Gyun Jee Song, Hyun Jeong Yang

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)


Treatment of multiple sclerosis is effective when anti-inflammatory, neuroprotective and regenerative strategies are combined. Dendropanax morbiferus (DM) has anti-inflammatory, anti-oxidative properties, which may be beneficial for multiple sclerosis. However, there have been no reports on the effects of DM on myelination, which is critical for regenerative processes. To know whether DM benefits myelination, we checked differentiation and myelination of oligodendrocytes (OLs) in various primary culture systems treated with DM leaf EtOH extracts or control. DM extracts increased the OL membrane size in the mixed glial and pure OL precursor cell (OPC) cultures and changed OL-lineage gene expression patterns in the OPC cultures. Western blot analysis of DM-treated OPC cultures showed upregulation of MBP and phosphorylation of ERK1/2. In myelinating cocultures, DM extracts enhanced OL differentiation, followed by increased axonal contacts and myelin gene upregulations such as Myrf, CNP and PLP. Phytochemical analysis by LC-MS/MS identified multiple components from DM extracts, containing bioactive molecules such as quercetin, cannabidiol, etc. Our results suggest DM extracts enhance OL differentiation, followed by an increase in membrane size and axonal contacts, thereby indicating enhanced myelination. In addition, we found that DM extracts contain multiple bioactive components, warranting further studies in relation to finding effective components for enhancing myelination.

Original languageEnglish
Article number190266
JournalRoyal Society Open Science
Issue number6
Publication statusPublished - 2019 Jun 1


  • Dendropanax morbiferus
  • Differentiation
  • Multiple sclerosis
  • Myelin
  • Oligodendrocyte

ASJC Scopus subject areas

  • General


Dive into the research topics of 'Dendropanax morbiferus leaf extract facilitates oligodendrocyte development'. Together they form a unique fingerprint.

Cite this