Design and synthesis of chiral hybrid spiro (isoxazole-isoxazoline) ligands

Priti S. Koranne, Tetsuya Tsujihara, Midori A. Arai, Gan B. Bajracharya, Takeyuki Suzuki, Kiyotaka Onitsuka, Hiroaki Sasai

Research output: Contribution to journalArticlepeer-review

29 Citations (Scopus)


Novel chiral hybrid ligands containing an unsymmetrical spiro[4.5]decane skeleton with isoxazole and isoxazoline as the two coordinating units have been synthesized. Pd complexes of these ligands were found to be effective in activating olefins towards enantioselective tandem cyclization of a dialkenyl alcohol, providing the cyclized products in up to 97% ee.

Original languageEnglish
Pages (from-to)919-923
Number of pages5
JournalTetrahedron Asymmetry
Issue number8
Publication statusPublished - 2007 May 16
Externally publishedYes

ASJC Scopus subject areas

  • Catalysis
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry


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