TY - JOUR
T1 - Design, synthesis and DNA cleaving profiles of hybrids containing the novel enediyne and naturally occurring DNA intercalates
AU - Toshima, Kazunobu
AU - Ohta, Kazumi
AU - Ohashi, Aya
AU - Nakamura, Takatsugu
AU - Nakata, Masaya
AU - Matsumura, Shuichi
PY - 1993/12/1
Y1 - 1993/12/1
N2 - The designed hybrids 5-11 containing the DNA cleavable enediyne 4 and naturally occurring DNA intercalators 12-18cleave DNA effectively under alkaline conditions without any additive; the hybrids 5 and 11 exhibit the strongest DNA-cleaving abilities with the identical high purine base (G>A) selectivities for their DNA-cleavage profiles.
AB - The designed hybrids 5-11 containing the DNA cleavable enediyne 4 and naturally occurring DNA intercalators 12-18cleave DNA effectively under alkaline conditions without any additive; the hybrids 5 and 11 exhibit the strongest DNA-cleaving abilities with the identical high purine base (G>A) selectivities for their DNA-cleavage profiles.
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U2 - 10.1039/C39930001525
DO - 10.1039/C39930001525
M3 - Article
AN - SCOPUS:37049078487
SN - 0022-4936
SP - 1525
EP - 1527
JO - Journal of the Chemical Society, Chemical Communications
JF - Journal of the Chemical Society, Chemical Communications
IS - 19
ER -