Detection of metastatic medullary thyroid cancer with 131I-MIBG scans in Sipple's syndrome

Hiroshi Itoh, Katsuji Sugie, Shigetake Toyooka, Mitsuo Kawase, Sakae Mukaino, Fumitada Hazama, Keigo Endo, Kanji Torizuka, Kazuwa Nakao, Hiroo Imura

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)


While 131I-meta-iodobenzyl guanidine (131I-MIBG) scanning has made possible the scintigraphic visualization of pheochromocytoma and neuroblastoma, an accumulation of this agent has recently been reported in medullary thyroid cancer. We present the case of a patient with Sipple's syndrome (multiple endocrine neoplasia type IIa), in whom we were able to identify distant metastases and local invasion of medullary thyroid cancer as well as primary thyroid tumour and right adrenal pheochromocytoma, using 131I-MIBG scans. This case highlights the usefulness of 131I-MIBG in the detection of metastatic medullary thyroid cancer and suggests that this agent may also be of therapeutic use in the treatment of tumours.

Original languageEnglish
Pages (from-to)502-504
Number of pages3
JournalEuropean Journal of Nuclear Medicine
Issue number12
Publication statusPublished - 1986 Apr
Externally publishedYes


  • I-MIGBG scans
  • MEA IIa
  • Medullary thyroid cancer
  • Pheochromocytoma
  • Sipple's syndrome

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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