Development and pathological changes of neurovascular unit regulated by hypoxia response in the retina

Research output: Chapter in Book/Report/Conference proceedingConference contribution

13 Citations (Scopus)


Retina is a highly vascularized tissue with a high oxygen and metabolic demand receiving light located in the back of the eye. The development and the maintenance of the retinal vasculature are important to regulate the homeostasis in the tissue. α Subunits of hypoxia-inducible factor (HIF) are key molecules in hypoxia response inducing genes required for cell survival such as vascular endothelial growth factor under hypoxia. Neurons, glia, and vascular endothelium cells interdependently form neurovascular unit in the retina tightly regulated by hypoxia response via HIF expression. A corruption of the precise hypoxia response in the developmental or matured retinal tissue may lead congenital vascular anomalies or adult neovascular ocular diseases. To regulate hypoxia response through HIF activity would be an ideal therapeutic target for these vision-threatening eye diseases.

Original languageEnglish
Title of host publicationNew Horizons in Neurovascular Coupling
Subtitle of host publicationA Bridge Between Brain Circulation and Neural Plasticity, 2016
EditorsKazuto Masamoto, Hajime Hirase, Katsuya Yamada
PublisherElsevier B.V.
Number of pages11
ISBN (Print)9780444637048
Publication statusPublished - 2016

Publication series

NameProgress in Brain Research
ISSN (Print)0079-6123
ISSN (Electronic)1875-7855


  • Developmental anomaly
  • Hypoxia-inducible factor
  • Neovascular ocular disease
  • Persistent hyperplastic primary vitreous
  • Retina
  • Vascular endothelial growth factor
  • Von Hippel-Lindau protein

ASJC Scopus subject areas

  • General Neuroscience


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