Development of a compact artificial gill using concentrated hemoglobin solution as the oxygen carrier

Ken Ichi Nagase, Fukashi Kohori, Kiyotaka Sakai

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)


An artificial gill was developed using a concentrated hemoglobin solution containing inositol hexaphosphate (IHP), as the oxygen carrier solution, with the oxygen affinity controlled by temperature. Oxygen dissolved in sea water is first taken up from water to the oxygen carrier solution at 293K. The oxygen carrier solution is then heated and the oxygen is released from the oxygen carrier solution to expired air at 310K. The enhancement factors of the oxygen carrier solution that indicate its performance were obtained from the oxygen uptake rate and oxygen release rate. The values were approximately 3 at oxygen uptake and 16 at oxygen release. The scale-up for a human being at rest was estimated using these values, and the optimal operating condition was determined. The required membrane surface area for a human being is 63.8m2. The oxygen partial pressure of inspiration is 20.7kPa, adequate for the respiration. These indicate the feasibility of a compact and portable artificial gill device.

Original languageEnglish
Pages (from-to)281-292
Number of pages12
JournalJournal of Membrane Science
Issue number1-2
Publication statusPublished - 2003 Apr 15
Externally publishedYes


  • Facilitated transport
  • Fiber membranes
  • Gas separation modules
  • Oxygen transfer

ASJC Scopus subject areas

  • Biochemistry
  • Materials Science(all)
  • Physical and Theoretical Chemistry
  • Filtration and Separation


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