Development of a highly selective fluorescence probe for hydrogen sulfide

Kiyoshi Sasakura; Kenjiro Hanaoka; Norihiro Shibuya; Yoshinori Mikami; Yuka Kimura; Toru Komatsu; Tasuku Ueno; Takuya Terai; Hideo Kimura; Tetsuo Nagano

doi:10.1021/ja207851s

Development of a highly selective fluorescence probe for hydrogen sulfide

Kiyoshi Sasakura, Kenjiro Hanaoka, Norihiro Shibuya, Yoshinori Mikami, Yuka Kimura, Toru Komatsu, Tasuku Ueno, Takuya Terai, Hideo Kimura, Tetsuo Nagano

Research output: Contribution to journal › Article › peer-review

592 Citations (Scopus)

Abstract

Hydrogen sulfide (H ₂S) has recently been identified as a biological response modifier. Here, we report the design and synthesis of a novel fluorescence probe for H ₂S, HSip-1, utilizing azamacrocyclic copper(II) ion complex chemistry to control the fluorescence. HSip-1 showed high selectivity and high sensitivity for H ₂S, and its potential for biological applications was confirmed by employing it for fluorescence imaging of H ₂S in live cells.

Original language	English
Pages (from-to)	18003-18005
Number of pages	3
Journal	Journal of the American Chemical Society
Volume	133
Issue number	45
DOIs	https://doi.org/10.1021/ja207851s
Publication status	Published - 2011 Nov 16
Externally published	Yes

ASJC Scopus subject areas

Catalysis
Chemistry(all)
Biochemistry
Colloid and Surface Chemistry

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10.1021/ja207851s

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title = "Development of a highly selective fluorescence probe for hydrogen sulfide",

abstract = "Hydrogen sulfide (H 2S) has recently been identified as a biological response modifier. Here, we report the design and synthesis of a novel fluorescence probe for H 2S, HSip-1, utilizing azamacrocyclic copper(II) ion complex chemistry to control the fluorescence. HSip-1 showed high selectivity and high sensitivity for H 2S, and its potential for biological applications was confirmed by employing it for fluorescence imaging of H 2S in live cells.",

author = "Kiyoshi Sasakura and Kenjiro Hanaoka and Norihiro Shibuya and Yoshinori Mikami and Yuka Kimura and Toru Komatsu and Tasuku Ueno and Takuya Terai and Hideo Kimura and Tetsuo Nagano",

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doi = "10.1021/ja207851s",

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AU - Sasakura, Kiyoshi

AU - Hanaoka, Kenjiro

AU - Shibuya, Norihiro

AU - Mikami, Yoshinori

AU - Kimura, Yuka

AU - Komatsu, Toru

AU - Ueno, Tasuku

AU - Terai, Takuya

AU - Kimura, Hideo

AU - Nagano, Tetsuo

PY - 2011/11/16

Y1 - 2011/11/16

N2 - Hydrogen sulfide (H 2S) has recently been identified as a biological response modifier. Here, we report the design and synthesis of a novel fluorescence probe for H 2S, HSip-1, utilizing azamacrocyclic copper(II) ion complex chemistry to control the fluorescence. HSip-1 showed high selectivity and high sensitivity for H 2S, and its potential for biological applications was confirmed by employing it for fluorescence imaging of H 2S in live cells.

AB - Hydrogen sulfide (H 2S) has recently been identified as a biological response modifier. Here, we report the design and synthesis of a novel fluorescence probe for H 2S, HSip-1, utilizing azamacrocyclic copper(II) ion complex chemistry to control the fluorescence. HSip-1 showed high selectivity and high sensitivity for H 2S, and its potential for biological applications was confirmed by employing it for fluorescence imaging of H 2S in live cells.

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JO - Journal of the American Chemical Society

JF - Journal of the American Chemical Society

IS - 45

ER -

Development of a highly selective fluorescence probe for hydrogen sulfide

Abstract

ASJC Scopus subject areas

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