Development of a micro optical diffusion sensor using laser-induced dielectrophoretic manipulation

Koichi Itani, Akira Ebisui, Yoshihiro Taguchi, Yuji Nagasaka

Research output: Contribution to journalArticlepeer-review


Department of System Design Engineering, Keio University, Japan We have developed a novel micro optical diffusion sensor (MODS) based on laser-induced dielectrophoresis (LIDEP), which enables rapid measurement with a small sample volume and on-site sensing of protein conformation. This paper presents the measurement principle, the chip design, and the validity of the proposed method. To verify the applicability of MODS, we confirmed a sinusoidal concentration distribution of polystyrene beads in a surface-modified microchannel generated by LIDEP force. The decay time of the diffusion of the concentration distribution agreed well with theoretical calculations, confirming the applicability of MODS as a technique for measuring the diffusion coefficient.

Original languageEnglish
Pages (from-to)344-354
Number of pages11
JournalHeat Transfer - Asian Research
Issue number5
Publication statusPublished - 2010 Jul 1


  • Diffusion coefficient
  • Laser-induced dielectrophoresis
  • MEMS
  • Self-assembled monolayer
  • Surface modification

ASJC Scopus subject areas

  • Condensed Matter Physics
  • Fluid Flow and Transfer Processes


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