Development of a non-invasive transcutaneous blood glucose monitoring method using an ISFET biosensor.

N. Ito, A. Saito, T. Kuriyama, J. Kimura, T. Arai, M. Kikuchi, S. Kayashima, N. Nagata

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)


A transcutaneous blood glucose monitoring method has been developed by combining an SOS/ISFET (silicone-on-sapphire/ion sensitive field effect transistor) biosensor with an SEF (suction effusion fluid) collecting technique. The SEF collecting cell has a stainless steel mesh at its bottom which is kept in a weak vacuum condition so as to suck up transcutaneous SEF and deposit it in a reservoir above. An ISFET biosensor, consisting of immobilized enzyme membranes, enables the detection of glucose concentrations in very small samples. The method has been successfully applied to non-invasive monitoring of human blood glucose levels during tests involving 75 g OGTT (oral glucose tolerance test). Glucose concentrations measured with SEF showed good correlation with those obtained directly from serum. Results suggest the feasibility of a portable blood monitoring system.

Original languageEnglish
Pages (from-to)35-45
Number of pages11
JournalFrontiers of medical and biological engineering : the international journal of the Japan Society of Medical Electronics and Biological Engineering
Issue number1
Publication statusPublished - 1992
Externally publishedYes

ASJC Scopus subject areas

  • Biophysics


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