Development of allergic bronchopulmonary aspergillosis in a patient with Crohn's disease

Hisashi Sasaki, Jun Miyata, Yohei Maki, Yoshifumi Kimizuka, Nobuyoshi Hayashi, Yuji Fujikura, Akihiko Kawana

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)


Allergic bronchopulmonary aspergillosis (ABPA) is an eosinophilic inflammatory condition characterized by exaggerated immune responses to the fungal genus Aspergillus. Pulmonary manifestations in patients with Crohn's disease (CD) are frequent comorbidities. A 66-year-old man with CD treated with an anti-tumor necrosis factor-α antibody presented with dyspnea. Laboratory findings of elevated blood eosinophils and total serum IgE and positive aspergillus-specific antibodies as well as imaging findings of central bronchiectasis and mucoid impaction indicated a diagnosis of ABPA. To our knowledge, this is the first report of ABPA arising in a patient with CD. We discuss the pathophysiological mechanism of this rare complication.

Original languageEnglish
Pages (from-to)2835-2838
Number of pages4
JournalInternal Medicine
Issue number19
Publication statusPublished - 2019
Externally publishedYes


  • Anti-tumor necrosis factor-α antibody
  • Aspergillus
  • Asthma
  • Inflammatory bowel disease
  • Pulmonary disorder

ASJC Scopus subject areas

  • Internal Medicine


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