Development of experimental cerebral malaria is independent of IL-23 and IL-17

Hidekazu Ishida; Chikako Matsuzaki-Moriya; Takashi Imai; Kunio Yanagisawa; Yoshihisa Nojima; Kazutomo Suzue; Makoto Hirai; Yoichiro Iwakura; Akihiko Yoshimura; Shinjiro Hamano; Chikako Shimokawa; Hajime Hisaeda

doi:10.1016/j.bbrc.2010.10.114

Development of experimental cerebral malaria is independent of IL-23 and IL-17

Hidekazu Ishida, Chikako Matsuzaki-Moriya, Takashi Imai, Kunio Yanagisawa, Yoshihisa Nojima, Kazutomo Suzue, Makoto Hirai, Yoichiro Iwakura, Akihiko Yoshimura, Shinjiro Hamano, Chikako Shimokawa, Hajime Hisaeda

Department of Microbiology and Immunology

Research output: Contribution to journal › Article › peer-review

30 Citations (Scopus)

Abstract

Cerebral malaria (CM) is the most severe complication of Plasmodium infection. Although inappropriate immune responses to Plasmodium falciparum are reported as the major causes of CM, the precise mechanisms for development remain unclear. IL-23 and IL-17 have critical roles in the onset of autoimmunity and inflammatory diseases triggered by microbial infections. Thus, we investigated the influence of IL-23 and IL-17 on experimental CM (ECM) using Plasmodium berghei ANKA infection of C57BL/6 mice. Both IL-23 deficient mice and wild-type (WT) mice developed ECM. IL-17 deficient mice also developed ECM, while IL-17 producing cells other than CD4 ⁺ T cells (Th17) were increased in WT mice that developed ECM. In conclusion, this study showed that IL-23 and IL-17 are not involved in ECM development.

Original language	English
Pages (from-to)	790-795
Number of pages	6
Journal	Biochemical and Biophysical Research Communications
Volume	402
Issue number	4
DOIs	https://doi.org/10.1016/j.bbrc.2010.10.114
Publication status	Published - 2010 Nov 26

Keywords

Cerebral malaria
IL-17
IL-23
Immune responses
Malaria

ASJC Scopus subject areas

Biophysics
Biochemistry
Molecular Biology
Cell Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.bbrc.2010.10.114

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title = "Development of experimental cerebral malaria is independent of IL-23 and IL-17",

abstract = "Cerebral malaria (CM) is the most severe complication of Plasmodium infection. Although inappropriate immune responses to Plasmodium falciparum are reported as the major causes of CM, the precise mechanisms for development remain unclear. IL-23 and IL-17 have critical roles in the onset of autoimmunity and inflammatory diseases triggered by microbial infections. Thus, we investigated the influence of IL-23 and IL-17 on experimental CM (ECM) using Plasmodium berghei ANKA infection of C57BL/6 mice. Both IL-23 deficient mice and wild-type (WT) mice developed ECM. IL-17 deficient mice also developed ECM, while IL-17 producing cells other than CD4 + T cells (Th17) were increased in WT mice that developed ECM. In conclusion, this study showed that IL-23 and IL-17 are not involved in ECM development.",

keywords = "Cerebral malaria, IL-17, IL-23, Immune responses, Malaria",

author = "Hidekazu Ishida and Chikako Matsuzaki-Moriya and Takashi Imai and Kunio Yanagisawa and Yoshihisa Nojima and Kazutomo Suzue and Makoto Hirai and Yoichiro Iwakura and Akihiko Yoshimura and Shinjiro Hamano and Chikako Shimokawa and Hajime Hisaeda",

note = "Funding Information: The authors thank Rumiko Koitabashi for handling and support with brain sections. This work was supported by grants from the Ministry of Education, Science Sport and Culture of Japan to H.H. ( 20390121 , 21022036 ). ",

year = "2010",

month = nov,

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doi = "10.1016/j.bbrc.2010.10.114",

language = "English",

volume = "402",

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journal = "Biochemical and Biophysical Research Communications",

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TY - JOUR

T1 - Development of experimental cerebral malaria is independent of IL-23 and IL-17

AU - Ishida, Hidekazu

AU - Matsuzaki-Moriya, Chikako

AU - Imai, Takashi

AU - Yanagisawa, Kunio

AU - Nojima, Yoshihisa

AU - Suzue, Kazutomo

AU - Hirai, Makoto

AU - Iwakura, Yoichiro

AU - Yoshimura, Akihiko

AU - Hamano, Shinjiro

AU - Shimokawa, Chikako

AU - Hisaeda, Hajime

N1 - Funding Information: The authors thank Rumiko Koitabashi for handling and support with brain sections. This work was supported by grants from the Ministry of Education, Science Sport and Culture of Japan to H.H. ( 20390121 , 21022036 ).

PY - 2010/11/26

Y1 - 2010/11/26

N2 - Cerebral malaria (CM) is the most severe complication of Plasmodium infection. Although inappropriate immune responses to Plasmodium falciparum are reported as the major causes of CM, the precise mechanisms for development remain unclear. IL-23 and IL-17 have critical roles in the onset of autoimmunity and inflammatory diseases triggered by microbial infections. Thus, we investigated the influence of IL-23 and IL-17 on experimental CM (ECM) using Plasmodium berghei ANKA infection of C57BL/6 mice. Both IL-23 deficient mice and wild-type (WT) mice developed ECM. IL-17 deficient mice also developed ECM, while IL-17 producing cells other than CD4 + T cells (Th17) were increased in WT mice that developed ECM. In conclusion, this study showed that IL-23 and IL-17 are not involved in ECM development.

AB - Cerebral malaria (CM) is the most severe complication of Plasmodium infection. Although inappropriate immune responses to Plasmodium falciparum are reported as the major causes of CM, the precise mechanisms for development remain unclear. IL-23 and IL-17 have critical roles in the onset of autoimmunity and inflammatory diseases triggered by microbial infections. Thus, we investigated the influence of IL-23 and IL-17 on experimental CM (ECM) using Plasmodium berghei ANKA infection of C57BL/6 mice. Both IL-23 deficient mice and wild-type (WT) mice developed ECM. IL-17 deficient mice also developed ECM, while IL-17 producing cells other than CD4 + T cells (Th17) were increased in WT mice that developed ECM. In conclusion, this study showed that IL-23 and IL-17 are not involved in ECM development.

KW - Cerebral malaria

KW - IL-17

KW - IL-23

KW - Immune responses

KW - Malaria

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Development of experimental cerebral malaria is independent of IL-23 and IL-17

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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