Development of microfluidic droplet shooter and its application to interface for mass spectrometry

Yutaka Kazoe, Yusuke Shimizu, Kyojiro Morikawa, Yasushi Terui, Takashi Irie, Takehiko Kitamori

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)


Gas/liquid microfluidics has developed for high-efficiency mass transport, mixing and reaction in various applications of chemical analysis and synthesis. However, ejection of uniform liquid droplets floating in gas phase from the microchannels with trajectory control is still challenging. In this study, we developed a method for shooting picoliter droplets in a controlled direction that utilizes microscale gas-phase laminar flows and applied it to a mass spectrometry (MS) interface. The principle of droplet shooting using two-step gas-phase flow focusing was proposed. A microfluidic device with a branched and stepped hydrophobic microchannel was fabricated by top-down glass fabrication technologies. We verified the shooting of droplets of aqueous and organic solvents in the volume range of 3.61–24.9 pL at kilohertz frequencies. A model that considers the capillary force and the drag force was verified to establish a design guideline. Utilizing the developed microfluidic droplet shooter, we demonstrated high-efficiency sample transport to a single quadrupole mass spectrometer. We verified a sample injection rate of approximately 100 % by ejection of picoliter droplets into an MS injection aperture of a 400-μm diameter and achieved detection of caffeine with 3 times higher sensitivity than conventional electrospray ionization interface with sample dispersion.

Original languageEnglish
Article number129957
JournalSensors and Actuators, B: Chemical
Publication statusPublished - 2021 Aug 1
Externally publishedYes


  • Droplet microfluidics
  • Droplet shooting
  • Gas-liquid
  • Mass spectrometry
  • Microchannel

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Instrumentation
  • Condensed Matter Physics
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Electrical and Electronic Engineering
  • Materials Chemistry


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