Development of photo-controllable hydrogen sulfide donor applicable in live cells

Naoki Fukushima, Naoya Ieda, Mitsuyasu Kawaguchi, Kiyoshi Sasakura, Tetsuo Nagano, Kenjiro Hanaoka, Naoki Miyata, Hidehiko Nakagawa

Research output: Contribution to journalArticlepeer-review

36 Citations (Scopus)


Hydrogen sulfide (H2S) has multiple physiological roles, for example, in vasodilation and inflammation. It is a highly reactive gas under ambient conditions, so controllable H2S donors are required for studying its biological functions. Here, we describe the design, synthesis and application of a H2S donor (SPD-2) that utilizes xanthone photochemistry to control H2S release. H2S generation from SPD-2 was completely dependent on UVA-irradiation (325-385 nm), as confirmed by methylene blue assay and by the use of a H2S-selective fluorescent probe. SPD-2 was confirmed to provide controlled H2S delivery in live cells, and should be suitable for various biological applications.

Original languageEnglish
Pages (from-to)175-178
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Issue number2
Publication statusPublished - 2015 Jan 15
Externally publishedYes


  • Caged HS
  • Hydrogen sulfide
  • Photolabile protecting group
  • Xanthone photocage

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry


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