Diabetes mellitus and cancer risk: Pooled analysis of eight cohort studies in Japan

Shizuka Sasazuki, Hadrien Charvat, Azusa Hara, Kenji Wakai, Chisato Nagata, Kozue Nakamura, Ichiro Tsuji, Yumi Sugawara, Akiko Tamakoshi, Keitaro Matsuo, Isao Oze, Tetsuya Mizoue, Keitaro Tanaka, Manami Inoue, Shoichiro Tsugane

Research output: Contribution to journalArticlepeer-review

91 Citations (Scopus)


Although a growing body of evidence suggests a link between diabetes and cancer, it is not clear whether diabetes independently increases the risk of cancer. We conducted a comprehensive assessment of the association between pre-existing diabetes and total and site-specific cancer risk based on a pooled analysis of eight cohort studies in Japan (>330 000 subjects). We estimated a summary hazard ratio by pooling study-specific hazard ratios for total and site-specific cancer by using a random-effects model. A statistically increased risk was observed for cancers at specific sites, such as colon (hazard ratio; HR = 1.40), liver (HR = 1.97), pancreas (HR = 1.85) and bile duct (HR = 1.66; men only). Increased risk was also suggested for other sites, and diabetes mellitus was associated with an overall 20% increased risk in total cancer incidence in the Japanese population. The association between these two diseases has important implications for reiterating the importance of controlling lifestyle factors and may suggest a possible strategy for cancer screening among patients with diabetes. Studies continuously investigating the risk factors for diabetes are also important.

Original languageEnglish
Pages (from-to)1499-1507
Number of pages9
JournalCancer science
Issue number11
Publication statusPublished - 2013 Nov
Externally publishedYes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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