Diagnostic significance of tumor markers for gynecologic malignancies

Daisuke Aoki, Akira Hirasawa, Nobuyuki Susumu

Research output: Contribution to journalReview articlepeer-review

4 Citations (Scopus)


Gynecologic malignancies include ovarian cancer, uterine cervical cancer, endometrial cancer, and trophoblastic neoplasms. With ovarian tumors, due to their location within the abdominal cavity, it is difficult to make a preoperative pathological diagnosis of cancer without laparotomy. From this point of view, the use of tumor markers that consist of carbohydrate antigens, such as CA 125, in addition to diagnostic imaging are useful in the diagnosis of ovarian cancer. SCC antigen, a marker for squamous cell carcinoma, is clinically useful in the management of advanced cervical cancer. At present, there are no useful tumor markers for endometrial cancer that exhibit both high sensitivity and specificity, although CA 125 is often used in clinical practice. Finally, human chorionic gonadotropin (hCG) serves as an ideal tumor marker for trophoblastic disease; however, the incidence of trophoblastic neoplasms has decreased dramatically with the incorporation of strict clinical management of post-molar disease as well as with the overall decrease in the number of pregnancies.

Original languageEnglish
Pages (from-to)411-416
Number of pages6
JournalGan to kagaku ryoho. Cancer & chemotherapy
Issue number3
Publication statusPublished - 2005 Mar

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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