Differences between infrared spectra of normal and neoplastic human gastric cells

Naoko Fujioka; Yuji Morimoto; Tsunenori Arai; Kyoko Takeuchi; Masahiko Yoshioka; Makoto Kikuchi

doi:10.1155/2004/347480

Differences between infrared spectra of normal and neoplastic human gastric cells

Naoko Fujioka, Yuji Morimoto, Tsunenori Arai, Kyoko Takeuchi, Masahiko Yoshioka, Makoto Kikuchi

Department of Applied Physics and Physico-Informatics

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Abstract

We investigated the differences in Fourier transform-infrared (FT-IR) spectra between normal and neoplastic human gastric cells. The infrared spectra derived from the cancer cells (AGS, SNU-1, and NCI-N87) showed a significant increase in infrared absorption in the band around 1240 cm^-1, 1120 cm^-1 and 1080 cm^-1, compared with those from the normal gastric epithelial cells we established in culture. In addition, frequency shifts of 4.6 cm^-1 and 3.8 cm^-1 were seen at the peak absorbance in the bands around 1240 cm^-1 and 1080 cm^-1, respectively. These spectral differences reflected the differences between the phosphate backbone in the normal and neoplastic human gastric cells. The present results suggest that FT-IR spectroscopy is a potential new tool for gastric cancer diagnosis.

Original language	English
Pages (from-to)	59-66
Number of pages	8
Journal	Spectroscopy
Volume	18
Issue number	1
DOIs	https://doi.org/10.1155/2004/347480
Publication status	Published - 2004

ASJC Scopus subject areas

Spectroscopy

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abstract = "We investigated the differences in Fourier transform-infrared (FT-IR) spectra between normal and neoplastic human gastric cells. The infrared spectra derived from the cancer cells (AGS, SNU-1, and NCI-N87) showed a significant increase in infrared absorption in the band around 1240 cm-1, 1120 cm-1 and 1080 cm-1, compared with those from the normal gastric epithelial cells we established in culture. In addition, frequency shifts of 4.6 cm-1 and 3.8 cm-1 were seen at the peak absorbance in the bands around 1240 cm-1 and 1080 cm-1, respectively. These spectral differences reflected the differences between the phosphate backbone in the normal and neoplastic human gastric cells. The present results suggest that FT-IR spectroscopy is a potential new tool for gastric cancer diagnosis.",

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T1 - Differences between infrared spectra of normal and neoplastic human gastric cells

AU - Fujioka, Naoko

AU - Morimoto, Yuji

AU - Arai, Tsunenori

AU - Takeuchi, Kyoko

AU - Yoshioka, Masahiko

AU - Kikuchi, Makoto

PY - 2004

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N2 - We investigated the differences in Fourier transform-infrared (FT-IR) spectra between normal and neoplastic human gastric cells. The infrared spectra derived from the cancer cells (AGS, SNU-1, and NCI-N87) showed a significant increase in infrared absorption in the band around 1240 cm-1, 1120 cm-1 and 1080 cm-1, compared with those from the normal gastric epithelial cells we established in culture. In addition, frequency shifts of 4.6 cm-1 and 3.8 cm-1 were seen at the peak absorbance in the bands around 1240 cm-1 and 1080 cm-1, respectively. These spectral differences reflected the differences between the phosphate backbone in the normal and neoplastic human gastric cells. The present results suggest that FT-IR spectroscopy is a potential new tool for gastric cancer diagnosis.

AB - We investigated the differences in Fourier transform-infrared (FT-IR) spectra between normal and neoplastic human gastric cells. The infrared spectra derived from the cancer cells (AGS, SNU-1, and NCI-N87) showed a significant increase in infrared absorption in the band around 1240 cm-1, 1120 cm-1 and 1080 cm-1, compared with those from the normal gastric epithelial cells we established in culture. In addition, frequency shifts of 4.6 cm-1 and 3.8 cm-1 were seen at the peak absorbance in the bands around 1240 cm-1 and 1080 cm-1, respectively. These spectral differences reflected the differences between the phosphate backbone in the normal and neoplastic human gastric cells. The present results suggest that FT-IR spectroscopy is a potential new tool for gastric cancer diagnosis.

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Differences between infrared spectra of normal and neoplastic human gastric cells

Abstract

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