Different chemo- and endocrino- sensitivity of MCF-7 cells with or without estradiol supplement in vitro

H. Tanino; T. Kubota; Yoshirou Saikawa; T. H. Kuo; T. Takeuchi; S. Kase; T. Furukawa; M. Kitajima; T. Sakurai; Y. Naito; R. M. Hoffman

Different chemo- and endocrino- sensitivity of MCF-7 cells with or without estradiol supplement in vitro

H. Tanino, T. Kubota, Yoshirou Saikawa, T. H. Kuo, T. Takeuchi, S. Kase, T. Furukawa, M. Kitajima, T. Sakurai, Y. Naito, R. M. Hoffman

Law School

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

The sensitivity of MCF-7 cells to tamoxifen (TAM) and mitomycin C (MMC) was assessed in rapidly and slowly growing cells with or without estradiol supplementation, respectively. The growth of MCF-7 was inhibited by MMC in a concentration-dependent manner with or without estradiol (E₂) supplementation. Preincubation with MMC suppressed subsequent E₂ stimulated growth of MCF-7. TAM inhibited the growth of MCF-7 supplemented with E₂, and preincubation with TAM prevented subsequent E₂ stimulated growth of MCF-7. However, TAM did not inhibit the growth of MCF-7 cells in E₂ free medium. These results suggested that MMC may be more effective than TAM on breast cancer cells in the dormant or slow-growth phase.

Original language	English
Pages (from-to)	1219-1221
Number of pages	3
Journal	Anticancer research
Volume	13
Issue number	4
Publication status	Published - 1993 Jan 1

Keywords

Breast cancer
Chemo-endocrine therapy
In vitro culture
Mitomycin C
Tamoxifen

ASJC Scopus subject areas

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Cite this

@article{51ae7aa49fae4d20b0b0bc60e9cf2cbe,

title = "Different chemo- and endocrino- sensitivity of MCF-7 cells with or without estradiol supplement in vitro",

abstract = "The sensitivity of MCF-7 cells to tamoxifen (TAM) and mitomycin C (MMC) was assessed in rapidly and slowly growing cells with or without estradiol supplementation, respectively. The growth of MCF-7 was inhibited by MMC in a concentration-dependent manner with or without estradiol (E2) supplementation. Preincubation with MMC suppressed subsequent E2 stimulated growth of MCF-7. TAM inhibited the growth of MCF-7 supplemented with E2, and preincubation with TAM prevented subsequent E2 stimulated growth of MCF-7. However, TAM did not inhibit the growth of MCF-7 cells in E2 free medium. These results suggested that MMC may be more effective than TAM on breast cancer cells in the dormant or slow-growth phase.",

keywords = "Breast cancer, Chemo-endocrine therapy, In vitro culture, Mitomycin C, Tamoxifen",

author = "H. Tanino and T. Kubota and Yoshirou Saikawa and Kuo, {T. H.} and T. Takeuchi and S. Kase and T. Furukawa and M. Kitajima and T. Sakurai and Y. Naito and Hoffman, {R. M.}",

year = "1993",

month = jan,

day = "1",

language = "English",

volume = "13",

pages = "1219--1221",

journal = "Anticancer research",

issn = "0250-7005",

publisher = "International Institute of Anticancer Research",

number = "4",

}

TY - JOUR

T1 - Different chemo- and endocrino- sensitivity of MCF-7 cells with or without estradiol supplement in vitro

AU - Tanino, H.

AU - Kubota, T.

AU - Saikawa, Yoshirou

AU - Kuo, T. H.

AU - Takeuchi, T.

AU - Kase, S.

AU - Furukawa, T.

AU - Kitajima, M.

AU - Sakurai, T.

AU - Naito, Y.

AU - Hoffman, R. M.

PY - 1993/1/1

Y1 - 1993/1/1

N2 - The sensitivity of MCF-7 cells to tamoxifen (TAM) and mitomycin C (MMC) was assessed in rapidly and slowly growing cells with or without estradiol supplementation, respectively. The growth of MCF-7 was inhibited by MMC in a concentration-dependent manner with or without estradiol (E2) supplementation. Preincubation with MMC suppressed subsequent E2 stimulated growth of MCF-7. TAM inhibited the growth of MCF-7 supplemented with E2, and preincubation with TAM prevented subsequent E2 stimulated growth of MCF-7. However, TAM did not inhibit the growth of MCF-7 cells in E2 free medium. These results suggested that MMC may be more effective than TAM on breast cancer cells in the dormant or slow-growth phase.

AB - The sensitivity of MCF-7 cells to tamoxifen (TAM) and mitomycin C (MMC) was assessed in rapidly and slowly growing cells with or without estradiol supplementation, respectively. The growth of MCF-7 was inhibited by MMC in a concentration-dependent manner with or without estradiol (E2) supplementation. Preincubation with MMC suppressed subsequent E2 stimulated growth of MCF-7. TAM inhibited the growth of MCF-7 supplemented with E2, and preincubation with TAM prevented subsequent E2 stimulated growth of MCF-7. However, TAM did not inhibit the growth of MCF-7 cells in E2 free medium. These results suggested that MMC may be more effective than TAM on breast cancer cells in the dormant or slow-growth phase.

KW - Breast cancer

KW - Chemo-endocrine therapy

KW - In vitro culture

KW - Mitomycin C

KW - Tamoxifen

UR - http://www.scopus.com/inward/record.url?scp=0027227537&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027227537&partnerID=8YFLogxK

M3 - Article

C2 - 8352547

AN - SCOPUS:0027227537

SN - 0250-7005

VL - 13

SP - 1219

EP - 1221

JO - Anticancer research

JF - Anticancer research

IS - 4

ER -

Different chemo- and endocrino- sensitivity of MCF-7 cells with or without estradiol supplement in vitro

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Other files and links

Fingerprint

Cite this